ACS Appl Bio Mater. 2023 Jun 19;6(6):2089-2101. doi: 10.1021/acsabm.3c00244. Epub 2023 May 24.
The cucurbit[]urils (CB[]) belong to the field of relatively young supramolecules which act as containers for a large variety of guests and are being explored extensively for their numerous biomedical applications. This includes drug formulation and delivery, controlled drug release, photodynamic therapy, sensing for bioanalytical purposes, etc. These supramolecular host-guest systems have distinctive recognition properties and have successfully been shown to enhance the and utility of various chemotherapeutic agents. The CB[]s are tailored to optimize their application in payload delivery and diagnostics and in lowering the toxicity of existing drugs. This review has listed the recent studies on working mechanisms and host-guest complexation of the biologically vital molecules with CB[] and highlighted their implementation in anticancer therapeutics. Various modifications in CB-drug inclusion compounds like CB supramolecular nanoarchitectures along with application in photodynamic therapy, which has shown potential as targeted drug delivery vehicles in cancer chemotherapy, have also been discussed.
葫芦脲[[]]属于相对较新的超分子领域，它们作为各种客体的容器，因其在众多生物医学应用中的广泛探索而备受关注。这包括药物制剂和递送、控制药物释放、光动力疗法、用于生物分析目的的传感等。这些超分子主客体体系具有独特的识别特性，并已成功证明可增强各种化疗药物的[[]]和[[]]。葫芦脲[[]]被定制以优化其在有效负载递送和诊断以及降低现有药物毒性方面的应用。本综述列出了关于与葫芦脲[[]]形成主客体配合物的生物重要分子的工作机制和主客体络合的最新研究，并强调了它们在抗癌治疗中的应用。还讨论了葫芦脲-药物包合物的各种修饰，如葫芦脲超分子纳米结构，以及在光动力疗法中的应用，光动力疗法已显示出作为癌症化学疗法中靶向药物递送载体的潜力。
