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FBLN5作为一种可能的预后基因，可能调节儿童和年轻成人肾透明细胞癌的肿瘤免疫微环境。

FBLN5 as One Presumably Prognostic Gene Potentially Modulating Tumor Immune Microenvironment for Renal Clear Cell Carcinoma in Children and Young Adults.

作者信息

Zhang Ming, Chen Feng, Feng Shaoguang, Liu Xu, Wang Zhen, Shen Nan, Meng Lingjian, Zhu Dongsheng, Zhu Zhitao

机构信息

Department of Pediatric Surgery, The First People's Hospital of Lianyungang, Lianyungang, People's Republic of China.

Department of Pediatric, Luodian Hospital, Shanghai, People's Republic of China.

出版信息

Pharmgenomics Pers Med. 2024 Jan 19;17:27-40. doi: 10.2147/PGPM.S442803. eCollection 2024.

DOI:10.2147/PGPM.S442803
PMID:38264064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10804877/
Abstract

OBJECTIVE

To investigate the role of FBLN5in renal clear cell carcinoma (KIRC), in particular on the tumor's immune microenvironment, including children and young adults.

METHODS

FBLN5 expression in tumor and normal samples was explored using SangerBox, TIMER2.0, GEPIA, UALCAN, HPA databases. The Linkedomics database was used to obtain FBLN5 co-expressed genes in KIRC tissue. SangerBox was also used to estimate immune infiltration of FBLN5 in KIRC. The Kaplan-Meier plotter was used to investigate the survival effects of FBLN5 expression in the presence of immune infiltration. We then collected 48 cases from 7 hospitals over a-20 year period to calculate the impact of FBLN5 on the prognosis of children and young adults with KIRC.

RESULTS

FBLN5 expression was significantly reduced in KIRC tissue compared to normal adjacent tissue. FBLN5 was potentially involved in the immune-related biological processes. In addition, FBLN5 expression has been linked to a number of immune checkpoints, cytokines, chemokines and chemokine receptors in KIRC. At the same time, the expression of FBLN5 affected the survival rates differently in KIRC patients with high or low levels of immune infiltration. High expression of FBLN5 in children and young adults with KIRC was associated with a favorable prognosis.

CONCLUSION

This study shed light on the potential of FBLN5 as a prognostic marker in children and young adults with KIRC and as an immune-related target for clinical treatment.

摘要

目的

探讨FBLN5在肾透明细胞癌（KIRC）中的作用，特别是对肿瘤免疫微环境的作用，包括儿童和青年患者。

方法

利用SangerBox、TIMER2.0、GEPIA、UALCAN、HPA数据库探究肿瘤和正常样本中FBLN5的表达情况。使用Linkedomics数据库获取KIRC组织中与FBLN5共表达的基因。SangerBox还用于评估FBLN5在KIRC中的免疫浸润情况。使用Kaplan-Meier绘图仪研究在存在免疫浸润的情况下FBLN5表达对生存的影响。然后在20年期间从7家医院收集了48例病例，以计算FBLN5对儿童和青年KIRC患者预后的影响。

结果

与相邻正常组织相比，KIRC组织中FBLN5表达显著降低。FBLN5可能参与免疫相关的生物学过程。此外，FBLN5表达与KIRC中的一些免疫检查点、细胞因子、趋化因子和趋化因子受体有关。同时，在免疫浸润水平高或低的KIRC患者中，FBLN5表达对生存率的影响不同。KIRC儿童和青年患者中FBLN5的高表达与良好预后相关。

结论

本研究揭示了FBLN5作为儿童和青年KIRC患者预后标志物以及作为临床治疗免疫相关靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/3a1c4117cf23/PGPM-17-27-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/d56b8214b530/PGPM-17-27-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/0f5c5d3d79a9/PGPM-17-27-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/346c50798dbd/PGPM-17-27-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/7dac32f9592e/PGPM-17-27-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/79c0818594b0/PGPM-17-27-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/65cab535410b/PGPM-17-27-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/3a1c4117cf23/PGPM-17-27-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/d56b8214b530/PGPM-17-27-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/0f5c5d3d79a9/PGPM-17-27-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/346c50798dbd/PGPM-17-27-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/7dac32f9592e/PGPM-17-27-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/79c0818594b0/PGPM-17-27-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/65cab535410b/PGPM-17-27-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3805/10804877/3a1c4117cf23/PGPM-17-27-g0007.jpg

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