Dulloo A G, Miller D S
Am J Physiol. 1987 Mar;252(3 Pt 2):R507-13. doi: 10.1152/ajpregu.1987.252.3.R507.
A thermogenic mixture containing ephedrine and methylxanthines was administered to 8-wk-old genetically obese fa/fa rats (O-E/Mx group) for a period of 15 wk. Their energy balance and the final body composition were compared with an untreated ad libitum-fed (O-AL) group, as well as to other fa/fa obese animals that were either pair fed to lean controls (O-PF group), or that were food restricted to such an extent they maintained a similar body weight to that of lean animals (O-WF group). Energy intake was elevated above lean or O-PF levels by approximately 27 and 10% in the O-AL and O-E/Mx groups, respectively, but lower by 18% in the O-WF group. Energy expenditure, compared with the lean values, was 10% higher in both the O-AL and O-E/Mx groups, but reduced by 13 and 30% in the O-PF and O-WF groups, respectively. The gain in body energy and the efficiency of energy deposition remained elevated above the lean values by 2.3- to 3.5-fold in the O-AL, O-PF, and O-WF groups but were reduced to lean levels in the O-E/Mx groups. These studies indicate that, unlike food restriction, the ephedrine-methylxanthine mixture prevents or arrests the development of the obesity in the fa/fa mutant by normalizing their energetic efficiency to that of the lean.
将含有麻黄碱和甲基黄嘌呤的产热混合物给予8周龄的遗传性肥胖fa/fa大鼠（O-E/Mx组），持续15周。将它们的能量平衡和最终身体组成与自由采食未处理的（O-AL）组进行比较，同时也与其他fa/fa肥胖动物进行比较，这些动物要么与瘦对照动物配对喂食（O-PF组），要么食物限制到维持与瘦动物相似体重的程度（O-WF组）。O-AL组和O-E/Mx组的能量摄入量分别比瘦动物或O-PF组的水平高出约27%和10%，但O-WF组低18%。与瘦动物的值相比，O-AL组和O-E/Mx组的能量消耗均高出10%，但O-PF组和O-WF组分别降低了13%和30%。O-AL组、O-PF组和O-WF组的身体能量增加和能量沉积效率比瘦动物的值高出2.3至3.5倍，但在O-E/Mx组中降至瘦动物水平。这些研究表明，与食物限制不同，麻黄碱-甲基黄嘌呤混合物通过将fa/fa突变体的能量效率恢复到瘦动物的水平，预防或阻止了肥胖的发展。
