Department of Respiratory and Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, China.
Front Cell Infect Microbiol. 2024 Jan 9;13:1320758. doi: 10.3389/fcimb.2023.1320758. eCollection 2023.
Research into the effects of pneumonia on the liver has emerged in the last few years. However, no studies have systematically described liver injury in patients with psittacosis. We present the first report on the clinical features and risk factors of liver injury in patients with pneumonia.
We retrospectively collected the clinical parameters for 46 patients with pneumonia admitted to Jinhua Central Hospital from January 2019 to February 2023. We analyzed the liver function parameters and summarized the clinical characteristics and risk factors of liver injury.
Among the 46 patients, 39 (84.8%) had abnormal liver function, and 23 (50.0%) had liver injury. The ratio of patients with a history of alcohol consumption (39.1% vs. 4.3%, =0.004) or severe pneumonia (56.5% vs. 26.1%, =0.036) was higher in the liver injury group compared with the non-liver injury group. Laboratory tests showed higher lactate dehydrogenase (LDH) levels in the liver injury group (0.001). The optimal cut-off LDH level associated with liver injury was 473 IU/L as determined by ROC curve analysis. Furthermore, multivariate logistic regression analysis demonstrated that a history of alcohol consumption (odds ratio [OR] = 11.251; 95% confidence interval [CI] = 1.022 ~ 123.897, =0.048) and an LDH level of ≥ 473IU/L (OR = 11.635, 95% CI = 1.832 ~ 73.869, =0.009) were independent risk factors for liver injury.
A history of alcohol consumption and an LDH level of over 473 IU/L are independent risk factors for pneumonia-related liver injury. It is recommended that particular attention be given to monitoring and evaluating liver function parameters when treating patients with pneumonia who have a high LDH level and history of alcohol consumption.
近年来，有关肺炎对肝脏影响的研究逐渐兴起。然而，目前尚无研究系统描述鹦鹉热患者的肝损伤情况。我们首次报道了肺炎患者肝损伤的临床特征和危险因素。
我们回顾性收集了 2019 年 1 月至 2023 年 2 月期间在金华市中心医院就诊的 46 例肺炎患者的临床参数。分析肝功能参数，总结肝损伤的临床特征和危险因素。
46 例患者中，39 例（84.8%）肝功能异常，23 例（50.0%）发生肝损伤。与无肝损伤组相比，有饮酒史（39.1%比 4.3%， =0.004）或重症肺炎（56.5%比 26.1%， =0.036）的患者比例更高。实验室检查显示，肝损伤组乳酸脱氢酶（LDH）水平更高（0.001）。通过 ROC 曲线分析，肝损伤的最佳截断 LDH 水平为 473IU/L。此外，多因素 logistic 回归分析表明，有饮酒史（比值比[OR] = 11.251；95%置信区间[CI] = 1.022 ~ 123.897， =0.048）和 LDH 水平≥473IU/L（OR = 11.635，95%CI = 1.832 ~ 73.869， =0.009）是肺炎相关肝损伤的独立危险因素。
有饮酒史和 LDH 水平超过 473IU/L 是肺炎相关肝损伤的独立危险因素。建议在治疗 LDH 水平较高和有饮酒史的肺炎患者时，特别注意监测和评估肝功能参数。
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