Huang He, Liu Yanquan, Liu Yuan, Lin Jie, Guo Huidong, Xu Qinglin, Zhang Hehui, Li Zuotao, Zhu Hongquan, Ding Mingli
The First Affiliated Hospital (The First School of Clinical Medicine) of Gannan Medical University, Ganzhou, Jiangxi, People's Republic of China.
The First School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, People's Republic of China.
Infect Drug Resist. 2024 Nov 28;17:5261-5275. doi: 10.2147/IDR.S486895. eCollection 2024.
To investigate and analyze the clinical features, diagnosis and treatment, and prognosis of rare pneumonia, and to improve the understanding of this rare disease.
A retrospective analysis and exploration was performed for 33 cases of patients with pneumonia in the First Affiliated Hospital of Gannan Medical University from January 2017 to March 2024, and the clinical features, diagnosis, treatment and key points for differential diagnosis were summarized and analyzed. Meanwhile, the latest literature from PubMed was retrieved to systematically discuss the research progress in pneumonia.
A total of 33 patients with pneumonia were included in this study, including 21 males (63.64%) and 12 females (36.36%), with a median age of 59 (32-79) years. There were 27 cases (81.82%) of patients accompanied with a history of poultry contact, 22 patients (66.67%) had underlying diseases. In our study, patients with pneumonia were mainly affected in Autumn (21.21%) and Winter (54.55%). All patients had undergone bronchoscopy and obtained bronchoalverolar lavage fluid (BALF) for metagenomic next-generation sequencing (mNGS) detection, and mNGS results showed that all patients (100%) were co-infected with multiple pathogens including . All patients were given antimicrobial therapy after diagnosis, and no treatment-related adverse reactions or adverse events were observed in our study, the average length of hospitalization was 11.09 days. Fortunately, no death was observed in our study, and patients were all discharged from hospital after recovery and in favourable physical and psychological conditions after discharge.
pneumonia lacks specific clinical features or manifestations and tends to develop into severe exacerbation. mNGS could help to achieve an accurate diagnosis. Early administration of antibiotics can improve the prognosis of patients to the greatest extent.
探讨和分析罕见肺炎的临床特征、诊断与治疗及预后，以提高对该罕见病的认识。
对2017年1月至2024年3月在赣南医学院第一附属医院收治的33例罕见肺炎患者进行回顾性分析与探究，总结分析其临床特征、诊断、治疗及鉴别诊断要点。同时检索PubMed的最新文献，系统探讨罕见肺炎的研究进展。
本研究共纳入33例罕见肺炎患者，其中男性21例（63.64%），女性12例（36.36%），中位年龄59（32 - 79）岁。有27例（81.82%）患者有家禽接触史，22例（66.67%）有基础疾病。在本研究中，罕见肺炎患者主要在秋季（21.21%）和冬季（54.55%）发病。所有患者均接受了支气管镜检查并获取支气管肺泡灌洗液（BALF）进行宏基因组下一代测序（mNGS）检测，mNGS结果显示所有患者（100%）均合并感染包括……在内的多种病原体。所有患者确诊后均给予抗菌治疗，本研究中未观察到与治疗相关的不良反应或不良事件，平均住院时间为11.09天。幸运的是，本研究中未观察到死亡病例，患者均康复出院，出院后身心状况良好。
罕见肺炎缺乏特异性临床特征或表现，且易发展为重症加重。mNGS有助于实现准确诊断。早期使用抗生素可最大程度改善患者预后。
