Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, P.R. China.
Clin Transl Med. 2024 Jan;14(1):e1545. doi: 10.1002/ctm2.1545.
The impact of fibroblasts on the immune system provides insight into the function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes interact with immunocytes by secreting growth factors, cytokines, and chemokines, leading to wound healing, fibrosis, and escape of cancer immune surveillance. However, the specific mechanisms involved in the fibroblast-immunocyte interaction network have not yet been fully elucidated.
Therefore, we systematically reviewed the molecular mechanisms of fibroblast-immunocyte interactions in fibrosis, from the history of cellular evolution and cell subtype divisions to the regulatory networks between fibroblasts and immunocytes. We also discuss how these communications function in different tissue and organ statuses, as well as potential therapies targeting the reciprocal fibroblast-immunocyte interplay in fibrosis. A comprehensive understanding of these functional cells under pathophysiological conditions and the mechanisms by which they communicate may lead to the development of effective and specific therapies targeting fibrosis.
成纤维细胞对免疫系统的影响为其功能研究提供了新视角。在各种组织微环境中，多种成纤维细胞亚型通过分泌生长因子、细胞因子和趋化因子与免疫细胞相互作用，导致伤口愈合、纤维化和癌症免疫逃逸。然而，成纤维细胞-免疫细胞相互作用网络中涉及的具体机制尚未完全阐明。
因此，我们系统地综述了纤维化中成纤维细胞-免疫细胞相互作用的分子机制，从细胞进化史和细胞亚型划分到成纤维细胞和免疫细胞之间的调控网络。我们还讨论了这些通讯在不同组织和器官状态下的功能，以及针对纤维化中纤维母细胞-免疫细胞相互作用的潜在治疗方法。全面了解这些在病理生理条件下发挥功能的细胞及其通讯机制，可能为靶向纤维化的有效和特异治疗方法的开发提供理论依据。
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