Post-graduation Program in Technological Development and Innovation in Medicines (PPgDITM) - Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
UNIFACISA - Campina Grande, PB, Brazil.
Anticancer Agents Med Chem. 2024;24(7):477-487. doi: 10.2174/0118715206269415231128100926.
Colorectal cancer is the third most common cancer and the second in cases of cancer-related death. Polytherapy generates many adverse effects, leading the patient to give up. Nanotechnology has been studied in recent years to circumvent limitations. Groups composed of polymeric, lipid, and inorganic nanoparticles are the most purpose. Thus, the objective of this work is to bring information on how nanosystems can improve the chemotherapeutic treatment for colorectal cancer. Therefore, a search in journals such as "LILACS", "SciELO" and "PubMed/Medline" was performed, resulting in 25,000 articles found when applied the search engines "nanoparticle," "colorectal cancer," "malignant neoplasms," and "chemotherapy." After inclusion and exclusion factors, 24 articles remained, which were used as the basis for this integrative review. The results reveal that, regardless of the choice of matrix, nanoparticles showed an increase in bioavailability of the active, increasing the half-life by up to 13 times, modified release, as well as a significant reduction in tumor size, with cell viability up to 20% lower than the free drug tested, in different colorectal cancer cell lines, such as HCT-116, HT-29, and CaCo-2. However, more in vivo and clinical studies need to be performed, regardless of the formulation of its matrix, aiming at a higher rate of safety for patients and stability of the formulations, as well as knowledge of detailed indices of its pharmacokinetics and pharmacodynamics, seeking to avoid further damage to the recipient organism.
结直肠癌是第三大常见癌症，也是癌症相关死亡的第二大原因。多疗法会产生许多不良反应，导致患者放弃治疗。近年来，纳米技术一直被研究用于规避这些限制。由聚合物、脂质和无机纳米粒子组成的纳米粒子组是最有针对性的。因此，本工作的目的是提供关于纳米系统如何改善结直肠癌的化疗治疗的信息。因此，在“LILACS”、“SciELO”和“PubMed/Medline”等期刊上进行了搜索，当应用搜索引擎“nanoparticle”、“colorectal cancer”、“malignant neoplasms”和“chemotherapy”时，共找到了 25000 篇文章。在纳入和排除因素后，剩下 24 篇文章，这些文章被用作这个综合评价的基础。结果表明，无论基质的选择如何，纳米粒子都显示出了活性物的生物利用度增加，半衰期延长了 13 倍，释放得到了修饰，以及肿瘤体积显著减小，与测试的游离药物相比，细胞活力降低了 20%，在不同的结直肠癌细胞系中，如 HCT-116、HT-29 和 CaCo-2。然而，无论其基质的配方如何，都需要进行更多的体内和临床研究，以提高患者的安全性和配方的稳定性，并了解其药代动力学和药效学的详细指标，以避免对受体器官的进一步损害。
