World-Class Research Center, Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia; Postal Address: Russia, Moscow, 8-2 Trubetskaya street, 119991.
Cardiovasc Hematol Agents Med Chem. 2024;22(4):466-474. doi: 10.2174/0118715257265595231128070227.
Numerous complications, such as postoperative arrhythmia and stroke, have been observed following coronary artery bypass graft (CABG) surgery.
This study sought to examine the impact of aging on the incidence of post-coronary artery shunt complications.
Aging is a physiological process experienced by every living cell, beginning early in development. Age plays a crucial role in determining postoperative complications, including those related to CABG.
A retrospective analysis was conducted on 290 patients who underwent CABG at the Mordovian Republic Hospital between 2017 and 2021. The sample was divided into two age-based groups: the first group comprised 126 patients (mean age range: 55.21-60.00), and the second group included 163 patients (mean age range: 66.11-80.00). Statistical analyses employed in this study encompassed descriptive statistics, Chi-square test, T-test, one-way ANOVA test, ROC analysis, and Pearson correlation using Statistica 12 software.
Elderly patients in the second group demonstrated a higher incidence of post-CABG arrhythmia (p < 0.012528). Moreover, the second group experienced markedly longer ICU and total hospitalization days following CABG, with p-values of less than 0.000000 and 0.000072, respectively. Notably, elderly individuals in the second group faced an increased risk of developing psychosis after CABG surgery (p < 0.007379). Furthermore, psychosis was found to be significantly associated with longer ICU hospitalization (p < 0.000140). Postoperative stroke occurred more frequently among the elderly (second group) with a p-value of less than 0.037736. Consequently, postoperative stroke was associated with extended ICU hospitalization (p < 0.000747). The usage of internal thoracic arteries (ITAs) was lower among the elderly (second group), with a p-value of less than 0.016145. Regarding correlations, a direct association was observed between age and ICU days, total hospitalization days, and the number of complications, with correlation coefficients (r) of 0.189046, 0.141415, and 0.138565, respectively.
Elderly individuals in the second group who undergo CABG face a greater risk of developing psychosis, arrhythmia, prolonged total and ICU hospitalization, and stroke. The presence of arrhythmia, which is commonly observed in patients aged 63 years and older, significantly affects total hospitalization days. The number of complications is influenced by age, cardiopulmonary bypass (CPB) time, aortic cross-clamp time, ICU hospitalization, and total hospitalization duration.
冠状动脉旁路移植术（CABG）后会出现许多并发症，如术后心律失常和中风。
本研究旨在探讨年龄对冠状动脉分流术后并发症发生率的影响。
衰老是每个活细胞经历的生理过程，从早期发育开始。年龄在确定术后并发症方面起着至关重要的作用，包括与 CABG 相关的并发症。
对 2017 年至 2021 年间在莫尔多瓦共和国医院接受 CABG 的 290 名患者进行了回顾性分析。样本分为两组：第一组 126 名患者（平均年龄范围：55.21-60.00），第二组 163 名患者（平均年龄范围：66.11-80.00）。本研究采用的统计分析包括描述性统计、卡方检验、T 检验、单因素方差分析、ROC 分析和使用 Statistica 12 软件的 Pearson 相关性分析。
第二组老年患者术后发生心律失常的发生率较高（p < 0.012528）。此外，第二组患者在 CABG 后 ICU 和总住院天数明显延长，p 值分别小于 0.000000 和 0.000072。值得注意的是，第二组老年患者在 CABG 术后发生精神病的风险增加（p < 0.007379）。此外，精神病与 ICU 住院时间延长显著相关（p < 0.000140）。老年患者（第二组）中风发生率较高，p 值小于 0.037736。因此，中风与 ICU 住院时间延长相关（p < 0.000747）。老年患者（第二组）内乳动脉（ITA）的使用率较低，p 值小于 0.016145。关于相关性，年龄与 ICU 天数、总住院天数和并发症数量之间存在直接关联，相关系数（r）分别为 0.189046、0.141415 和 0.138565。
接受 CABG 的第二组老年患者发生精神病、心律失常、总住院时间和 ICU 住院时间延长以及中风的风险更高。63 岁及以上患者常见的心律失常显著影响总住院时间。并发症数量受年龄、体外循环（CPB）时间、主动脉阻断时间、ICU 住院时间和总住院时间的影响。
