Pavlov Institute of Physiology RAS, Makarov Nab., 6, Saint-Petersburg, Russia, 199034.
Brain Struct Funct. 2024 Mar;229(2):489-495. doi: 10.1007/s00429-023-02752-6. Epub 2024 Jan 24.
The perigeniculate nucleus (PGN) is a visual part of the thalamic reticular nucleus modulating the information transfer between the lateral geniculate nucleus and the visual cortex. This study focused on the postnatal development of the PGN in cats, using the SMI-32 antibody, which recognizes non-phosphorylated heavy-chain neurofilaments responsible for neuronal structural maturation and is also used as a marker for motion processing, or Y, stream. We questioned whether transient neuronal populations exist in the PGN and can they possibly be related to the Y processing stream. We uncovered a transient, robust SMI-32 staining in the PGN of kittens aged 0-34 days with the significant decline in the cellular density of labeled cells in older animals. According to the double-labeling, in all examined age groups, perigeniculate SMI-32-immunopositive cells are part of the main parvalbumin-positive population. The maximal cellular density of the double-stained cells appeared in animals aged 10-28 days. We also revealed that the most significant growth of perigeniculate cells's soma occurred at three postnatal weeks. The possible link of our data to the development of the Y visual processing stream and to the heterogeneity of the perigeniculate neuronal population is also discussed.
围核（PGN）是丘脑网状核的视觉部分，调节外侧膝状体核和视皮层之间的信息传递。本研究使用 SMI-32 抗体聚焦于猫的 PGN 的出生后发育，该抗体识别非磷酸化的重链神经丝，负责神经元结构成熟，也被用作运动处理或 Y 流的标志物。我们质疑 PGN 中是否存在短暂的神经元群体，它们是否可能与 Y 处理流有关。我们发现，在 0-34 日龄的小猫的 PGN 中存在短暂而强烈的 SMI-32 染色，而在较年长的动物中标记细胞的细胞密度显著下降。根据双重标记，在所有检查的年龄组中，围核 SMI-32 免疫阳性细胞是主要的副钙蛋白阳性群体的一部分。双染色细胞的最大细胞密度出现在 10-28 日龄的动物中。我们还揭示了围核细胞体的最大生长发生在出生后三周。我们的数据与 Y 视觉处理流的发展和围核神经元群体的异质性之间的可能联系也进行了讨论。
