国际肺癌筛查试验澳大利亚队列中肺癌筛查问卷心理社会后果的验证
Validation of the psychosocial consequences of screening in lung cancer questionnaire in the international lung screen trial Australian cohort.
作者信息
Bonney Asha, Brodersen John, Siersma Volkert, See Katharine, Marshall Henry M, Steinfort Daniel, Irving Louis, Lin Linda, Li Jiashi, Pang Siyuan, Fogarty Paul, Brims Fraser, McWilliams Annette, Stone Emily, Lam Stephen, Fong Kwun M, Manser Renee
机构信息
Department of Medicine, University of Melbourne, Melbourne, Australia.
Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC, Australia.
出版信息
Health Qual Life Outcomes. 2024 Jan 25;22(1):10. doi: 10.1186/s12955-023-02225-8.
BACKGROUND
Evaluation of psychosocial consequences of lung cancer screening with LDCT in high-risk populations has generally been performed using generic psychometric instruments. Such generic instruments have low coverage and low power to detect screening impacts. This study aims to validate an established lung cancer screening-specific questionnaire, Consequences Of Screening Lung Cancer (COS-LC), in Australian-English and describe early results from the baseline LDCT round of the International Lung Screen Trial (ILST).
METHODS
The Danish-version COS-LC was translated to Australian-English using the double panel method and field tested in Australian-ILST participants to examine content validity. A random sample of 200 participants were used to assess construct validity using Rasch item response theory models. Reliability was assessed using classical test theory. The COS-LC was administered to ILST participants at prespecified timepoints including at enrolment, dependent of screening results.
RESULTS
Minor linguistic alterations were made after initial translation of COS-LC to English. The COS-LC demonstrated good content validity and adequate construct validity using psychometric analysis. The four core scales fit the Rasch model, with only minor issues in five non-core scales which resolved with modification. 1129 Australian-ILST participants were included in the analysis, with minimal psychosocial impact observed shortly after baseline LDCT results.
CONCLUSION
COS-LC is the first lung cancer screening-specific questionnaire to be validated in Australia and has demonstrated excellent psychometric properties. Early results did not demonstrate significant psychosocial impacts of screening. Longer-term follow-up is awaited and will be particularly pertinent given the announcement of an Australian National Lung Cancer Screening Program.
TRIAL REGISTRATION
NCT02871856.
背景
在高危人群中，一般使用通用心理测量工具对低剂量计算机断层扫描（LDCT）肺癌筛查的心理社会后果进行评估。这类通用工具检测筛查影响的覆盖范围低且效能不足。本研究旨在验证一份既定的肺癌筛查专用问卷——肺癌筛查后果问卷（COS-LC）的澳大利亚英语版本，并描述国际肺癌筛查试验（ILST）基线LDCT轮次的早期结果。
方法
采用双盲法将丹麦语版的COS-LC翻译成澳大利亚英语，并在澳大利亚ILST参与者中进行现场测试，以检验内容效度。使用拉施克项目反应理论模型，对200名参与者的随机样本进行结构效度评估。采用经典测试理论评估信度。在预定时间点，包括入组时（取决于筛查结果），对ILST参与者进行COS-LC问卷调查。
结果
COS-LC最初翻译成英语后进行了细微的语言修改。通过心理测量分析，COS-LC显示出良好的内容效度和足够的结构效度。四个核心量表符合拉施克模型，五个非核心量表仅有小问题，经修改后得到解决。1129名澳大利亚ILST参与者纳入分析，在基线LDCT结果公布后不久，观察到的心理社会影响极小。
结论
COS-LC是澳大利亚首个经过验证的肺癌筛查专用问卷，已证明具有出色的心理测量特性。早期结果未显示筛查有显著的心理社会影响。有待进行长期随访，鉴于澳大利亚国家肺癌筛查计划的宣布，这将尤为重要。
试验注册
NCT02871856
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