Sacks P, Fellner S K
Arch Intern Med. 1987 Mar;147(3):593-5.
A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effective arterial volume, may activate tubuloglomerular feedback, thereby contributing to acute renal failure.
一名患有隐源性肝硬化和播散性孢子丝菌病的患者，在4次单独使用两性霉素B后均立即出现急性肾衰竭。肾衰竭的突发性及其在数天内的可逆性表明，肾功能障碍存在功能性因素。我们认为，在有效动脉血容量减少的情况下，两性霉素可能会激活肾小管-肾小球反馈，从而导致急性肾衰竭。
