Arcas-Bellas José J, Siljeström Roberto, Sánchez Cristina, González Ana, García-Fernández Javier
Department of Anesthesia and Critical Care, Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain.
Transplant Direct. 2024 Jan 24;10(2):e1564. doi: 10.1097/TXD.0000000000001564. eCollection 2024 Feb.
The intraoperative management of patients undergoing orthotopic liver transplantation (OLT) is influenced by the cardiovascular manifestations typically found in the context of end-stage liver disease, by the presence of concomitant cardiovascular disease, and by the significant hemodynamic changes that occur during surgery. Hypotension and intraoperative blood pressure fluctuations during OLT are associated with liver graft dysfunction, acute kidney failure, and increased risk of 30-d mortality. Patients also frequently present hemodynamic instability due to various causes, including cardiac arrest. Recent evidence has shown transesophageal echocardiography (TEE) to be a useful minimally invasive monitoring tool in patients undergoing OLT that gives valuable real-time information on biventricular function and volume status and can help to detect OLT-specific complications or situations. TEE also facilitates rapid diagnosis of life-threatening conditions in each stage of OLT, which is difficult to identify with other types of monitoring commonly used. Although there is no consensus on the best approach to intraoperative monitoring in these patients, intraoperative TEE is safe and useful and should be recommended during OLT, according to experts, for assessing hemodynamic changes, identifying possible complications, and guiding treatment with fluids and inotropes to achieve optimal patient care.
原位肝移植(OLT)患者的术中管理受到多种因素影响,这些因素包括终末期肝病常见的心血管表现、合并存在的心血管疾病以及手术过程中发生的显著血流动力学变化。OLT术中低血压和血压波动与肝移植功能障碍、急性肾衰竭以及30天死亡率增加相关。患者还常因包括心脏骤停在内的各种原因出现血流动力学不稳定。最近的证据表明,经食管超声心动图(TEE)是OLT患者一种有用的微创监测工具,它能提供有关双心室功能和容量状态的有价值实时信息,并有助于检测OLT特有的并发症或情况。TEE还便于在OLT的每个阶段快速诊断危及生命的状况,而这用其他常用监测类型很难识别。尽管对于这些患者术中监测的最佳方法尚无共识,但据专家称,术中TEE安全且有用,在OLT期间应推荐使用,以评估血流动力学变化、识别可能的并发症,并指导液体和血管活性药物治疗,以实现对患者的最佳护理。