Shi Jiatian, Zhang Xinyue, Chen Jianhua, Shen Ruishi, Cui Huashun, Wu Huangan
Department of Acupuncture and Moxibustion, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Mental Health, Shanghai Mental Health Center, Shanghai, China.
Front Neurosci. 2024 Jan 11;17:1275860. doi: 10.3389/fnins.2023.1275860. eCollection 2023.
Cognitive impairment poses a significant burden on individuals, families, and society worldwide. Despite the lack of effective treatment strategies, emerging evidence suggests that the microbiome-gut-brain (MGB) axis may play a critical role in the pathogenesis of cognitive impairment. While targeted treatment is not yet comprehensive, recently, acupuncture and moxibustion therapy has participated increasingly in the treatment of degenerative diseases and has achieved a certain therapeutic effect. In this review, the possible mechanisms by which acupuncture and moxibustion therapy may improve cognitive impairment through the MGB axis are reviewed, including regulating gut microbial homeostasis, improving intestinal inflammation mediated by the neuroendocrine-immune system, and enhancing intestinal barrier function. We also discuss common acupoints and corresponding mechanism analysis to provide insights into further exploration of mechanisms that target the MGB axis and thereby intervene in cognitive impairment.
认知障碍给全球范围内的个人、家庭和社会带来了沉重负担。尽管缺乏有效的治疗策略，但新出现的证据表明，微生物群-肠道-脑（MGB）轴可能在认知障碍的发病机制中起关键作用。虽然靶向治疗尚不全面，但最近，针灸疗法越来越多地参与到退行性疾病的治疗中，并取得了一定的治疗效果。在这篇综述中，我们回顾了针灸疗法可能通过MGB轴改善认知障碍的潜在机制，包括调节肠道微生物稳态、改善神经内分泌-免疫系统介导的肠道炎症以及增强肠道屏障功能。我们还讨论了常用穴位及相应的机制分析，以期为进一步探索靶向MGB轴并干预认知障碍的机制提供思路。
