Liu Zhifeng, Jiao Yi, Yu Tianyuan, Wang Hourong, Zhang Yingqi, Liu Di, Xu Yajing, Guan Qian, Lu Mengqian
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 102488, China.
Acupuncture Department, Oriental Hospital of Beijing University of Chinese Medicine, Beijing 100078, China.
Evid Based Complement Alternat Med. 2022 Jan 15;2022:8528938. doi: 10.1155/2022/8528938. eCollection 2022.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease with a high prevalence and canceration rate. The immune disorder is one of the recognized mechanisms. Acupuncture is widely used to treat patients with IBD. In recent years, an increasing number of studies have proven the effectiveness of acupuncture in the treatment of IBD, and some progress has been made in the mechanism. In this paper, we reviewed the studies related to acupuncture for IBD and focused on the immunomodulatory mechanism. We found that acupuncture could regulate the innate and adaptive immunity of IBD patients in many ways. Acupuncture exerts innate immunomodulatory effects by regulating intestinal epithelial barrier, toll-like receptors, NLRP3 inflammasomes, oxidative stress, and endoplasmic reticulum stress and exerts adaptive immunomodulation by regulating the balance of Th17/Treg and Th1/Th2 cells. In addition, acupuncture can also regulate intestinal flora.
炎症性肠病（IBD）是一种患病率和癌变率都很高的慢性炎症性疾病。免疫紊乱是公认的发病机制之一。针灸被广泛用于治疗IBD患者。近年来，越来越多的研究证实了针灸治疗IBD的有效性，并且在作用机制方面取得了一些进展。在本文中，我们回顾了与针灸治疗IBD相关的研究，并重点关注免疫调节机制。我们发现，针灸可以通过多种方式调节IBD患者的固有免疫和适应性免疫。针灸通过调节肠道上皮屏障、Toll样受体、NLRP3炎性小体、氧化应激和内质网应激发挥固有免疫调节作用，并通过调节Th17/Treg和Th1/Th2细胞平衡发挥适应性免疫调节作用。此外，针灸还可以调节肠道菌群。
