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以成骨细胞性病变为首发表现的胃混合型腺癌:一例报告

Osteoblastic Lesions as the First Presentation of a Gastric Mixed-Type Adenocarcinoma: A Case Report.

作者信息

de Almeida Patrícia Amaral, Carvalho André, Guedes Fátima, Bessa Isabel, Gonçalves Abílio

机构信息

Internal Medicine, Hospital Distrital da Figueira da Foz, Figueira da Foz, PRT.

出版信息

Cureus. 2023 Dec 26;15(12):e51121. doi: 10.7759/cureus.51121. eCollection 2023 Dec.

Abstract

Bone metastasis might be associated with several tumors; however, the association between gastric malignant neoplasms and bone secondary lesions is very rare, with the osteoblastic form having the rarest presentation. In fact, osteoblastic lesions, as the first presentation of gastric adenocarcinomas, are even rarer and known to have a very poor prognosis associated with them. Therefore, we present a clinical case of a patient with lower back pain as the first symptom, which led to the diagnosis of osteoblastic lesions of the spine and iliac bones, suggested as secondary lesions. Later, the investigation of the primary tumor led to the diagnosis of a gastric adenocarcinoma (stage IV disease). In this report, we highlight the steps taken for the etiological study course and the challenges associated with them from the beginning. We also emphasize the very unfavorable evolution of our patient, with the inability to carry out targeted treatment, neither curative nor palliative, due to the advanced stage of the disease and the very poor survival time associated with it.

摘要

骨转移可能与多种肿瘤相关;然而,胃恶性肿瘤与骨继发性病变之间的关联非常罕见,成骨型表现最为罕见。事实上,成骨病变作为胃腺癌的首发表现更为罕见,且已知其预后很差。因此,我们报告一例临床病例,患者以腰痛为首发症状,最终诊断为脊柱和髂骨的成骨病变,提示为继发性病变。后来,对原发肿瘤的检查导致诊断为胃腺癌(IV期疾病)。在本报告中,我们重点介绍了病因学研究过程中采取的步骤以及从一开始就与之相关的挑战。我们还强调了我们这位患者的病情进展非常不利,由于疾病晚期以及与之相关的极差生存时间,无法进行靶向治疗,无论是根治性还是姑息性治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6239/10810169/86c3e73e15c7/cureus-0015-00000051121-i01.jpg

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