持续性妊娠滋养细胞肿瘤的成功管理：全面综述与病例分析
Successful Management of Persistent Gestational Trophoblastic Neoplasia: A Comprehensive Review and Case Analysis.
作者信息
Das Susmita, Sethy Madhusmita, Das Siddharth Sankar, Maniyar Pawan Kumar J
机构信息
Obstetrics and Gynaecology, Aster DM Hospital, Dubai, ARE.
Pathology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.
出版信息
Cureus. 2023 Dec 26;15(12):e51112. doi: 10.7759/cureus.51112. eCollection 2023 Dec.
Gestational trophoblastic disease comprises hydatidiform mole (HM) (complete or partial) and gestational trophoblastic neoplasia (GTN). Complete and partial moles have different karyotypes, gross and microscopic histopathology, clinical presentation, prognosis, and chances of progress to GTN. Ultrasonography (USG) and human chorionic gonadotropin (hCG) quantification are commonly used to diagnose molar pregnancy and further follow-up until resolution. Our case reports two patients, one with a complete mole and another with a partial mole, who were evaluated and followed up with serial beta hCG as per protocol and were found to have persistent disease and referred for chemotherapy until complete resolution. Fifteen to 20% of the patients with complete moles and about 1-5% of patients with partial moles developed GTN, which is primarily invasive. Hence, proper follow-up and chemotherapy assure 100% curability.
妊娠滋养细胞疾病包括葡萄胎（完全性或部分性）和妊娠滋养细胞肿瘤（GTN）。完全性和部分性葡萄胎在核型、大体和微观组织病理学、临床表现、预后以及发展为GTN的可能性方面存在差异。超声检查（USG）和人绒毛膜促性腺激素（hCG）定量常用于诊断葡萄胎妊娠并进行进一步随访直至病情缓解。我们的病例报告了两名患者，一名为完全性葡萄胎，另一名为部分性葡萄胎，他们按照方案接受了连续β-hCG评估和随访，结果发现患有持续性疾病，并被转诊接受化疗直至完全缓解。15%至20%的完全性葡萄胎患者和约1%至5%的部分性葡萄胎患者会发展为主要具有侵袭性的GTN。因此，适当的随访和化疗可确保100%的治愈率。
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