Mosca Antonella, Manco Melania, Braghini Maria Rita, Cianfarani Stefano, Maggiore Giuseppe, Alisi Anna, Vania Andrea
Hepatology and Liver Transplant Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Preventive and Predictive Medicine Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071.
Ecological theories suggest that environmental factors significantly influence obesity risk and related syndemic morbidities, including metabolically abnormal obesity associated with nonalcoholic fatty liver disease (MASLD). These factors encompass anthropogenic influences and endocrine-disrupting chemicals (EDCs), synergistically interacting to induce metabolic discrepancies, notably in early life, and disrupt metabolic processes in adulthood. This review focuses on endocrine disruptors affecting a child's MASLD risk, independent of their role as obesogens and thus regardless of their impact on adipogenesis. The liver plays a pivotal role in metabolic and detoxification processes, where various lipophilic endocrine-disrupting molecules accumulate in fatty liver parenchyma, exacerbating inflammation and functioning as new anthropogenics that perpetuate chronic low-grade inflammation, especially insulin resistance, crucial in the pathogenesis of MASLD.
生态学理论表明，环境因素会显著影响肥胖风险及相关综合征性疾病，包括与非酒精性脂肪性肝病（MASLD）相关的代谢异常肥胖。这些因素包括人为影响和内分泌干扰化学物质（EDC），它们协同作用，诱发代谢差异，尤其是在生命早期，并扰乱成年期的代谢过程。本综述聚焦于影响儿童MASLD风险的内分泌干扰物，独立于它们作为致肥胖物的作用，因此不论其对脂肪生成的影响。肝脏在代谢和解毒过程中起关键作用，各种亲脂性内分泌干扰分子在脂肪肝实质中蓄积，加剧炎症，并作为新的人为因素使慢性低度炎症持续存在，尤其是胰岛素抵抗，这在MASLD发病机制中至关重要。
