一种基于微环谐振器阵列的无标记光学生物传感器用于检测人血清白蛋白。

A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin.

作者信息

Chen Xin, Li Mingyu, Wang Zhaoyu, Zhao Kaihao, Gu Jiamei, Li Qiushun, He Jian-Jun

机构信息

Department of Optical Engineering, School of Opto-Electronic Engineering, Changchun University of Science and Technology, Changchun 130022, China.

State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China.

出版信息

Sensors (Basel). 2024 Jan 21;24(2):677. doi: 10.3390/s24020677.

DOI:10.3390/s24020677

PMID:38276369

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10818899/

Abstract

We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demonstrates high sensitivity at 168 nm/RIU and a low limit of detection (LOD) of 63.54 ng/mL, closely comparable to current HSA detection methods. These findings confirm the potential of MRRs as biocompatible sensors for HSA detection. This system holds great promise as an innovative platform for the detection of HSA, carrying significant importance in medical diagnostics.

摘要

我们介绍了一种基于微环谐振器（MRR）阵列的无标记传感系统，该系统已成功用于人血清白蛋白（HSA）检测。传感环表面经过功能化处理以固定抗HSA，便于HSA结合。我们的折射率传感系统在168 nm/RIU处显示出高灵敏度，检测限（LOD）低至63.54 ng/mL，与当前的HSA检测方法相当。这些发现证实了MRR作为用于HSA检测的生物相容性传感器的潜力。该系统作为检测HSA的创新平台具有巨大潜力，在医学诊断中具有重要意义。