Pennsylvania State University, Ross and Carol Nese College of Nursing, University Park, PA.
University of Maryland, School of Nursing, Baltimore, MD.
Alzheimer Dis Assoc Disord. 2024;38(1):28-33. doi: 10.1097/WAD.0000000000000601. Epub 2024 Jan 22.
This study investigated whether demographic characteristics (age, sex, and race) moderated delirium severity as a predictor of physical function in hospitalized persons living with dementia.
The sample consisted of 351 patients enrolled in a randomized controlled trial (Function Focused Care for Acute Care Using the Evidence Integration Triangle). Preliminary analysis was conducted to assess the main effect, and multiple linear regression was used to examine the moderating effect of demographic characteristics between delirium severity and physical function.
Both age and sex were found to have significant moderating effects on the relationship between delirium severity and physical function (β = 2.22; P = 0.02 and β = 1.34; P = 0.04, respectively). Older adults aged 85 years or older with higher levels of delirium severity reported lower levels of physical function compared with older adults aged 65 to 84 years. Males with higher levels of delirium severity reported lower levels of physical function compared with females. Race did not significantly moderate the association between delirium severity and physical function (β = 0.22; P = 0.90).
Our findings suggest that age and sex may have differential effects on physical function across different levels of delirium severity in hospitalized persons living with dementia.
本研究旨在探讨人口统计学特征（年龄、性别和种族）是否调节了谵妄严重程度作为预测痴呆住院患者身体功能的指标。
该样本由 351 名参加随机对照试验（使用证据整合三角的急性护理功能焦点护理）的患者组成。进行初步分析以评估主要效应，并用多元线性回归检验人口统计学特征在谵妄严重程度和身体功能之间的调节作用。
年龄和性别均对谵妄严重程度与身体功能之间的关系具有显著的调节作用（β=2.22；P=0.02 和β=1.34；P=0.04）。与 65 至 84 岁的老年人相比，85 岁或以上的老年患者谵妄严重程度较高，身体功能水平较低。与女性相比，谵妄严重程度较高的男性报告的身体功能水平较低。种族并不显著调节谵妄严重程度与身体功能之间的关联（β=0.22；P=0.90）。
我们的研究结果表明，年龄和性别可能对痴呆住院患者不同程度的谵妄严重程度对身体功能的影响存在差异。
