Nakamura T, Kato I, Kanayama R, Koike Y
Auris Nasus Larynx. 1986;13 Suppl 2:S97-103. doi: 10.1016/s0385-8146(86)80062-1.
A computer program was developed for on-line analysis of nystagmus parameters using a microcomputer (SORD M243EX). In this paper, the clinical utilities of microcomputer analysis of optokinetic nystagmus (OKN) were described, and quantitative analysis of each parameter of OKN was performed in 20 normal subjects and 49 patients with central nervous system (CNS) disorders. The average gain was accurately measured and the maximal stimulus velocity during which time the gain was more than 0.8, was termed as the "optokinetic adaptation limit (OAL)," and used as a clinical index for evaluation of OKN abnormalities. All patients in the present study showed a remarkable decrease in OAL. The differences in OAL among these patients at each level of lesion site, however, proved to be statistically insignificant. The relationship between the direction of OKN limitation and the lesion side was investigated. In all patients who had lesions on the thalamus, midbrain, and cerebellum, OKN limitation was observed toward the lesion side. The OKN limitation, however, was seen toward the intact side in 7 of 11 patients with medullary lesions and in 2 of 11 patients with cerebellopontine angle (CPA) tumors. hence, OKN in a useful diagnostic tool for the assessment of infratentorial lesions and computer analysis of OKN may be clinically useful.
利用一台微型计算机（SORD M243EX）开发了一种用于在线分析眼球震颤参数的计算机程序。本文描述了微型计算机对视动性眼球震颤（OKN）分析的临床应用，并对20名正常受试者和49例中枢神经系统（CNS）疾病患者的OKN各参数进行了定量分析。准确测量了平均增益，将增益大于0.8时的最大刺激速度称为“视动适应极限（OAL）”，并将其用作评估OKN异常的临床指标。本研究中的所有患者均显示OAL显著降低。然而，这些患者在每个病变部位水平的OAL差异在统计学上无显著性。研究了OKN受限方向与病变侧的关系。在所有丘脑、中脑和小脑有病变的患者中，观察到OKN向病变侧受限。然而，在11例延髓病变患者中的7例和11例桥小脑角（CPA）肿瘤患者中的2例中，OKN受限见于健侧。因此，OKN是评估幕下病变的一种有用诊断工具，OKN的计算机分析可能具有临床应用价值。
