Kanayama R, Kato I, Nakamura T, Koike Y
Department of Otolaryngology, School of Medicine, Yamagata University, Japan.
Acta Otolaryngol. 1987 Nov-Dec;104(5-6):392-9. doi: 10.3109/00016488709128266.
The fast phase of optokinetic nystagmus (OKN) in patients with central nervous system (CNS) disorders was quantitatively evaluated using a micro-computer. The relationship between peak velocity of the fast phases of OKN (velocity(p] versus amplitude was recognized to be best fitted to an exponential equation, i.e., velocity(p) = K(1-exp[-amplitude/L]). In patients with lesions in thalamus, midbrain, or pons, the velocity(p) was significantly reduced, whereas in patients with lesions in the medulla or the cerebellum, it was normal. The directional asymmetry of velocity(p) toward the lesion side indicated that the velocity(p) toward the intact side was significantly reduced as compared with that toward the lesion side in patients with lesions in the thalamus or midbrain, whereas in patients with lesions in the pons, the velocity(p) toward the lesion side had decreased significantly as compared with that toward the intact side. Thus the quantitative evaluation of velocity(p) may provide some important information on the mapping of lesions in patients with CNS disorders.
使用微型计算机对中枢神经系统（CNS）疾病患者的视动性眼震（OKN）快相进行了定量评估。OKN快相的峰值速度（velocity(p)）与振幅之间的关系被认为最符合指数方程，即velocity(p) = K(1-exp[-amplitude/L])。在丘脑、中脑或脑桥有病变的患者中，velocity(p)显著降低，而在延髓或小脑有病变的患者中，其值正常。velocity(p)向病变侧的方向不对称表明，在丘脑或中脑有病变的患者中，与向病变侧相比，向健侧的velocity(p)显著降低，而在脑桥有病变的患者中，与向健侧相比，向病变侧的velocity(p)显著降低。因此，对velocity(p)的定量评估可能为CNS疾病患者的病变定位提供一些重要信息。
