Ruiz-Muñoz Maria, Martinez-Barrios Francisco-Javier, Fernandez-Torres Raul, Lopezosa-Reca Eva, Marchena-Rodriguez Ana
Department Nursing and Podiatry, Faculty of Health Sciences, University of Málaga, Málaga, Spain.
J Diabetes Complications. 2024 Feb;38(2):108690. doi: 10.1016/j.jdiacomp.2024.108690. Epub 2024 Jan 19.
This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate.
The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS 25.0.
Eleven RCTs with 828 patients were included in this study. The meta-analysis showed a higher complete ulcer healing rate (OR = 3.69, 95 % CI 2.62 to 5.20, P < 0.01, I = 0 %) in growth factors based in autologous platelech-rich plasma (aPRP) group compared with control. Mixed evidence was seen for publication bias, but analyses by using the trim-and-fill method did not appreciably alter results.
Autologous platelet-rich plasma can improve the complete healing rate of the ulcer compared to current conventional treatments in diabetic foot ulcer patients.
本研究将基于溃疡愈合率，探讨与传统治疗方法相比，自体富血小板血浆治疗糖尿病足疾病的有效性。
检索了PubMed、EMBASE和WOS互联网的电子数据库。评估溃疡完全愈合的结局率。使用RevMan 5.0软件和SPSS 25.0进行统计分析。
本研究纳入了11项随机对照试验，共828例患者。荟萃分析显示，与对照组相比，基于自体富血小板血浆（aPRP）的生长因子组溃疡完全愈合率更高（OR = 3.69，95%CI 2.62至5.20，P < 0.01，I = 0%）。发现了关于发表偏倚的混合证据，但使用修剪填充法进行的分析并未明显改变结果。
与目前糖尿病足溃疡患者的传统治疗方法相比，自体富血小板血浆可提高溃疡的完全愈合率。
