Department of Endocrinology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):45-50. doi: 10.14715/cmb/2023.69.14.8.
The objective of this work was to investigate the factors influencing parathyroid function (PTF) after surgery for papillary thyroid carcinoma (PTC) and the relationship of serum 1,25(OH)2D3 and serum phosphorus to parathyroid hormone (PTH) levels. 113 patients with papillary thyroid carcinoma (PTC) were enrolled, including 75 patients with lowered PTF (70 patients with temporary (temporary reduction group) and 5 patients with permanent (permanent reduction group)) and 38 patients with normal PTF (normal group). The results of detection indexes showed that the serum PTH levels were decreased to different degrees compared with those before surgery. Serum 1,25(OH)2D3 levels decreased less in the normal group before and after surgery but decreased more in the temporary and permanent reduction groups. The change range of blood phosphorus before and after the surgery was small in the normal group, and the increase ranges in the temporary and permanent reduction groups were larger. The lowered PTF was negatively correlated with age and blood phosphorus (P<0.01) but positively correlated with serum PTH (P<0.05) and serum 1,25(OH)2D3 (P<0.01). In conclusion, lowered PTF after surgery for PTC was negatively correlated with blood phosphorus, which can indicate a decrease in PTH levels in patients. Meanwhile, the lowered PTF was positively correlated with serum PTH and serum 1,25(OH)2D3 levels.
本研究旨在探讨甲状腺乳头状癌（PTC）术后甲状旁腺功能（PTF）的影响因素，以及血清 1,25（OH）2D3 和血清磷与甲状旁腺激素（PTH）水平的关系。本研究共纳入 113 例 PTC 患者，其中 75 例 PTF 降低（70 例为暂时性（暂时性降低组）和 5 例为永久性（永久性降低组）），38 例 PTF 正常（正常组）。检测指标结果显示，与术前相比，血清 PTH 水平均有不同程度的降低。与术前相比，正常组血清 1,25（OH）2D3 水平降低较少，但在暂时性和永久性降低组中降低较多。正常组手术前后血磷变化幅度较小，而在暂时性和永久性降低组中增加幅度较大。PTF 降低与年龄和血磷呈负相关（P<0.01），与血清 PTH 和血清 1,25（OH）2D3 呈正相关（P<0.05）。综上所述，PTC 术后 PTF 降低与血磷呈负相关，可提示患者 PTH 水平降低。同时，PTF 降低与血清 PTH 和血清 1,25（OH）2D3 水平呈正相关。
