Jia J K, Lou D X, Zhu P
Renal Unit, Second Hospital, Zhejang Medical University, Hangzhou.
Zhonghua Nei Ke Za Zhi. 1994 Jan;33(1):33-6.
The changes of plasma PTH, 1,25(OH)2D3, serum calcium, phosphorus and AKP were observed in 55 uremic patients with renal osteodystrophy. The results showed that: In all types of renal osteodystrophy, plasma PTH were markedly higher than normal (P < 0.001), while plasma 1,25(OH)2D3 and serum calcium were lower than normal (P < 0.001). In low bone-turnover uremic osteodystrophy (LTO), plasma phosphorus was markedly lower than that of high bone-turnover uremic osteodystrophy (HTO) and mixed uremic osteodystrophy (MO) (P < 0.05), and plasma 1,25(OH)2D3 was significantly lower than that of HTO (P < 0.05). In HTO and MO, serum phosphorus was much higher than normal (P < 0.001). Plasma PTH had a negative linear correlation with plasma 1,25(OH)2D3 (P < 0.05), a positive linear correlation with serum AKP (P < 0.05), but no linear correlation with the duration of hemodialysis, serum calcium, serum aluminum and bone aluminum content. Plasma 1,25(OH)2D3 had no linear correlation with the duration of hemodialysis, serum phosphorus, serum aluminum and bone aluminum content. There was no significant difference in the plasma PTH, 1,25(OH)2D3 and serum AKP between the bone aluminum stain positive and negative groups.
观察55例患有肾性骨营养不良的尿毒症患者血浆甲状旁腺激素（PTH）、1,25-二羟维生素D3[1,25(OH)2D3]、血清钙、磷及碱性磷酸酶（AKP）的变化。结果显示：在所有类型的肾性骨营养不良中，血浆PTH均显著高于正常（P<0.001），而血浆1,25(OH)2D3和血清钙低于正常（P<0.001）。在低骨转换型尿毒症骨营养不良（LTO）中，血浆磷显著低于高骨转换型尿毒症骨营养不良（HTO）和混合型尿毒症骨营养不良（MO）（P<0.05），且血浆1,25(OH)2D3显著低于HTO（P<0.05）。在HTO和MO中，血清磷远高于正常（P<0.001）。血浆PTH与血浆1,25(OH)2D3呈负线性相关（P<0.05），与血清AKP呈正线性相关（P<0.05），但与血液透析时间、血清钙、血清铝及骨铝含量无线性相关。血浆1,25(OH)2D3与血液透析时间、血清磷、血清铝及骨铝含量无线性相关。骨铝染色阳性组与阴性组之间的血浆PTH、1,25(OH)2D3及血清AKP无显著差异。
