A组链球菌及其他一些细菌种类的肽聚糖的生物学特性。II. 血小板溶解所涉及的免疫机制。

Biological characteristics of peptidoglycans of group A streptococcus and some other bacterial species. II. Immunological mechanisms involved in thrombocytolysis.

作者信息

Rýc M, Rotta J

出版信息

J Hyg Epidemiol Microbiol Immunol. 1978;22(4):435-41.

Abstract

Immunological mechanisms are involved in the thrombocytolytic activity of peptidoglycan of Group A streptococcus, Streptococcus pneumoniae and Staphylococcus aureus. Inactivation of particular components of complement (heating of blood serum to 56 degrees C,incubation with zymosan or NH4OH) inhibited the thrombocytolytic activity of group A streptococcus peptidoglycan. So did preincubation of Group A streptococcus peptidoglycan with homologous antipeptidoglycan antibody. On the other hand, antibody to Group A streptococcus peptidoglycan did not inhibit the thrombocytolytic effect of Streptococcus pneumoniae or Staphylococcus aureus peptidoglycan. Human platelets are resistant to peptidoglycans. They remain resistant in the presence of rabbit serum although rabbit platelets are highly sensitive to peptidoglycans. This suggests that, for the expression of the thrombocytolytic activity of bacterial peptidoglycan, specific receptors on the surface of platelets must be present in addition to serum factors.

摘要

免疫机制参与了A组链球菌、肺炎链球菌和金黄色葡萄球菌肽聚糖的血小板溶解活性。补体特定成分的失活（将血清加热至56摄氏度、与酵母聚糖或氢氧化铵孵育）抑制了A组链球菌肽聚糖的血小板溶解活性。用同源抗肽聚糖抗体对A组链球菌肽聚糖进行预孵育也有同样的效果。另一方面，A组链球菌肽聚糖抗体并不抑制肺炎链球菌或金黄色葡萄球菌肽聚糖的血小板溶解作用。人血小板对肽聚糖具有抗性。尽管兔血小板对肽聚糖高度敏感，但人血小板在存在兔血清的情况下仍保持抗性。这表明，为了表达细菌肽聚糖的血小板溶解活性，除血清因子外，血小板表面还必须存在特定受体。