双氢麦角毒碱与硫利达嗪联合使用对大鼠自愿乙醇摄入量的抑制作用。
Inhibition of voluntary ethanol intake in rats by a combination of dihydroergotoxine and thioridazine.
作者信息
Fadda F, Franch F, Mosca E, Meloni R, Gessa G L
出版信息
Alcohol Drug Res. 1987;7(4):285-90.
PMID:3828005
Abstract
Dihydroergotoxine (DHET) decreased voluntary ethanol intake in rats selected for their stable ethanol preference (mean daily ethanol intake 8 g/kg). DHET inhibition was markedly potentiated by thioridazine. The potentiation is explained with a synergistic inhibitory effect on dopaminergic transmission: that is, DHET acting on dopamine (DA) autoreceptors and thioridazine preferentially inhibiting postsynaptic DA receptors.
摘要
双氢麦角毒碱（DHET）降低了对乙醇有稳定偏好（平均每日乙醇摄入量8克/千克）的大鼠的自愿乙醇摄入量。硫利达嗪显著增强了DHET的抑制作用。这种增强作用可以用对多巴胺能传递的协同抑制作用来解释：也就是说，DHET作用于多巴胺（DA）自身受体，而硫利达嗪优先抑制突触后DA受体。
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