Schreiber V, Pribyl T, Jahodová J
Physiol Bohemoslov. 1987;36(1):9-13.
The injection of oestradiol benzoate as an aqueous microcrystal suspension, in a dose of 1 mg twice a week, evokes a marked adenohypophyseal growth reaction in male rats. The reaction is potentiated by dopaminergic antagonists from the group of neuroleptics (specifically perphenazine and thioridazine). Elicitation of the same adenohypophyseal reaction required twice as much thioridazine (10 mg/rat per day) as perphenazine. Thyroxine inhibited the adenohypophyseal growth reaction to oestradiol. The serum polyphenol oxidase (ceruloplasmin) level rose after oestradiol and perphenazine and thioridazine slightly potentiated the increase.
以水微晶悬液形式注射苯甲酸雌二醇，剂量为每周两次，每次1毫克，可在雄性大鼠中引发明显的腺垂体生长反应。该反应可被抗精神病药物组中的多巴胺能拮抗剂（特别是奋乃静和硫利达嗪）增强。引发相同的腺垂体反应，硫利达嗪所需剂量（每天10毫克/只大鼠）是奋乃静的两倍。甲状腺素抑制了腺垂体对雌二醇的生长反应。雌二醇注射后血清多酚氧化酶（铜蓝蛋白）水平升高，奋乃静和硫利达嗪可轻微增强这种升高。
