Moss H B, Salin-Pascual R J, Rathnagiri P, Goldman D, Tamarkin L
Alcohol Drug Res. 1987;7(4):301-7.
Because male Syrian hamsters demonstrate greater preference for ethanol than female hamsters, we compared them with regard to ethanol sensitivity and hepatic alcohol and aldehyde dehydrogenase activities. Male hamsters were slower to recover righting response and had lower blood alcohol levels upon recovery than did females. Hepatic alcohol dehydrogenase activity was approximately twice as high in females as males, but gender differences were not found for either cytosolic or non-cytosolic aldehyde dehydrogenase activities. The results suggest that the reduced ethanol sensitivity of female hamsters is due to more rapid metabolism. However, the finding that female hamsters have higher blood alcohol concentrations upon recovery also suggests the possibility of reduced CNS sensitivity.
由于雄性叙利亚仓鼠对乙醇的偏好高于雌性仓鼠，我们比较了它们在乙醇敏感性以及肝脏酒精和醛脱氢酶活性方面的差异。雄性仓鼠恢复翻正反射的速度较慢，恢复时的血液酒精水平也低于雌性仓鼠。雌性仓鼠的肝脏酒精脱氢酶活性约为雄性的两倍，但胞质或非胞质醛脱氢酶活性均未发现性别差异。结果表明，雌性仓鼠乙醇敏感性降低是由于代谢更快。然而，雌性仓鼠恢复时血液酒精浓度较高这一发现也表明存在中枢神经系统敏感性降低的可能性。
