Usatenko M S, Petrova M A, Sokolovskaia N E, Anakina R P, Borodkin Iu S
Tsitologiia. 1989 May;31(5):604-7.
White rats were divided into water-preferring (WP) and ethanol-preferring (EP) groups, on the basis of their preferable drink: either water or 15% solution of ethanol. Each of these groups was then subdivided into groups which were given to drink for 1 year 15% solution of ethanol (ethanol-treated) or water (controls). Alcohol dehydrogenase/aldehyde dehydrogenase activity ratios (ADH/AlDH) in livers of WP controls were considerably higher than those in EP controls. The difference in ADH/AlDH has somewhat decreased after ethanol treatment. However, this ratio remained the highest in the WP alcohol-treated group. The signs of proteinic and lipid dystrophy of the liver in alcohol-treated WP rats were expressed much more clearly than in all other groups. It is concluded that in the liver of animals with a high ADH/AlDH ratio there are favourable conditions for accumulation of a toxic hepatocyte-damaging acetaldehyde.
根据对白鼠偏爱的饮品（水或15%乙醇溶液），将其分为喜水组（WP）和喜乙醇组（EP）。然后将每组再细分为饮用15%乙醇溶液1年的组（乙醇处理组）和饮用清水的组（对照组）。喜水对照组肝脏中的乙醇脱氢酶/乙醛脱氢酶活性比（ADH/AlDH）显著高于喜乙醇对照组。乙醇处理后，ADH/AlDH的差异有所减小。然而，该比值在喜水组乙醇处理组中仍最高。乙醇处理的喜水组大鼠肝脏中蛋白质和脂质营养不良的迹象比所有其他组都更明显。得出的结论是，在ADH/AlDH比值高的动物肝脏中，存在有利于毒性肝细胞损伤性乙醛积累的条件。
