缺乏味觉新皮质的大鼠的酒精偏好

Alcohol preference in rats lacking gustatory neocortex.

作者信息

Kiefer S W, Lawrence G J, Metzler C W

出版信息

Alcohol. 1987 Jan-Feb;4(1):37-43. doi: 10.1016/0741-8329(87)90058-9.

Abstract

Ingestion of alcohol solutions (in concentrations from 0.5 to 12% v/v) was examined in three experiments where rats lacking gustatory neocortex (GN) were compared with intact and control lesion rats. Two experiments tested alcohol consumption during a restricted schedule of fluid access with one or two bottle tests. The last experiment involved testing with continuous access to water and alcohol solutions in two bottle tests. Subgroups of rats in each experiment were presented with either an ascending or descending order of concentrations. In all experiments, GN rats consumed less total fluid during testing (relative to control rats). In general, GN rats exhibited similar patterns of alcohol consumption as that found in control rats. Where differences between GN rats and control rats were found, GN rats consumed more alcohol than control rats during tests with restricted fluid access. During continuous fluid access, however, no significant differences between GN rats and control rats were found.

摘要

在三个实验中研究了大鼠对酒精溶液（浓度为0.5%至12%体积/体积）的摄入情况，将缺乏味觉新皮层（GN）的大鼠与完整大鼠和对照损伤大鼠进行了比较。两个实验通过一或两个瓶子测试，在限制饮水时间表期间测试酒精消耗量。最后一个实验涉及在两个瓶子测试中连续提供水和酒精溶液的情况下进行测试。每个实验中的大鼠亚组被给予浓度由低到高或由高到低的顺序。在所有实验中，GN大鼠在测试期间摄入的总液体量较少（相对于对照大鼠）。一般来说，GN大鼠表现出与对照大鼠相似的酒精消耗模式。在发现GN大鼠和对照大鼠存在差异的情况下，在限制饮水测试中，GN大鼠比对照大鼠消耗更多的酒精。然而，在连续饮水期间，未发现GN大鼠和对照大鼠之间存在显著差异。