味觉和嗅觉对大鼠酒精摄入的影响。

Gustatory and olfactory contributions to alcohol consumption in rats.

作者信息

Morrow N S, Kiefer S W, Metzler C W

机构信息

Department of Psychology, Kansas State University, Manhattan 66506.

出版信息

Alcohol. 1993 Jul-Aug;10(4):263-7. doi: 10.1016/0741-8329(93)90003-7.

DOI:10.1016/0741-8329(93)90003-7

PMID:8397876

Abstract

To determine the relative contributions of taste and smell in the consumption of alcohol by rats, the present experiment tested normal rats (n = 14) and rats with either gustatory cortex ablations (n = 10), olfactory bulbectomies (n = 11), or combination gustatory cortex and olfactory bulb ablations (n = 12). Rats were tested under mild fluid deprivation using a two-bottle testing procedure. Thirteen concentrations of alcohol (0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, and 12%, v/v) were tested in ascending order. Results showed that at strong alcohol concentrations (7% through 11%) rats with combined gustatory cortex and olfactory bulb ablations consumed significantly more alcohol than normal control rats. Rats lacking gustatory cortex displayed a similar increased level of consumption with strong alcohol concentrations. It is suggested that the high level of consumption of strong alcohol concentrations by rats with central nervous system damage reflects an associative deficit rather than an alteration in taste or odor perception.

摘要

为了确定味觉和嗅觉在大鼠酒精摄入中的相对作用，本实验对正常大鼠（n = 14）以及味觉皮层切除的大鼠（n = 10）、嗅球切除的大鼠（n = 11）或味觉皮层和嗅球联合切除的大鼠（n = 12）进行了测试。使用双瓶测试程序在轻度液体剥夺条件下对大鼠进行测试。按升序测试了13种酒精浓度（0.5%、1%、2%、3%、4%、5%、6%、7%、8%、9%、10%、11%和12%，v/v）。结果表明，在高浓度酒精（7%至11%）条件下，味觉皮层和嗅球联合切除的大鼠比正常对照大鼠摄入的酒精显著更多。缺乏味觉皮层的大鼠在高浓度酒精条件下也表现出类似的摄入量增加。这表明中枢神经系统受损的大鼠对高浓度酒精的高摄入量反映的是一种联合缺陷，而非味觉或气味感知的改变。