大鼠口服给药后，3-氨基-1,2,4-三唑预处理对血液乙醇水平无影响。
Absence of effect of 3-amino-1,2,4-triazole pretreatment on blood ethanol levels after oral administration, in rats.
作者信息
Tampier L, Mardones J
出版信息
Alcohol. 1987 Jan-Feb;4(1):73-4. doi: 10.1016/0741-8329(87)90064-4.
PMID:3828068
Abstract
Blood ethanol levels registered in rats receiving 90 mmole/kg by gavage were not different in rats pretreated with aminotriazole (1 g/kg IP) 1 hour before, than in untreated controls. Results are consistent with the idea that no measurable gastrointestinal catalase first pass effect is present in rats.
摘要
通过灌胃给予90毫摩尔/千克乙醇的大鼠，其血液乙醇水平在1小时前腹腔注射氨基三唑（1克/千克）预处理的大鼠与未处理的对照组之间并无差异。结果与大鼠不存在可测量的胃肠道过氧化氢酶首过效应这一观点一致。
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