Galante D, Esposito S, Barba D
Boll Ist Sieroter Milan. 1986;65(5):361-7.
Three hundred eighty seven gram negative bacterial strains were isolated from urine specimens of as many patients affected by urinary tract infections. Susceptibility of bacteria to six quinolones (ciprofloxacin, norfloxacin, oxolinic, nalidixic, pipemidic acid and cinoxacin) and six beta-lactams (ceftazidime, ceftizoxime, ceftriaxone, cefamandole, cefoxitin and cefotaxime) was studied determining the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of each compound by a miniaturized dilution broth method. Ciprofloxacin, a quinoline carboxylic acid compound structurally related to nalidixic acid, and ceftazidime a new beta-lactamase stable beta-lactam showed a much higher antibacterial activity against all the bacterial strains including Pseudomonas. The best antibacterial activity of ciprofloxacin and ceftazidime was expressed either by the lower MICs and lower MBCs with respect to those of the other compounds or by a low MBC/MIC ratio, which represent an important clinical advantage in clinical practice.
从患有尿路感染的患者尿液标本中分离出387株革兰氏阴性菌。通过微型稀释肉汤法测定每种化合物的最低抑菌浓度（MIC）和最低杀菌浓度（MBC），研究了这些细菌对六种喹诺酮类药物（环丙沙星、诺氟沙星、恶喹酸、萘啶酸、吡哌酸和西诺沙星）和六种β-内酰胺类药物（头孢他啶、头孢唑肟、头孢曲松、头孢孟多、头孢西丁和头孢噻肟）的敏感性。环丙沙星是一种与萘啶酸结构相关的喹啉羧酸化合物，头孢他啶是一种新型的对β-内酰胺酶稳定的β-内酰胺类药物，它们对包括假单胞菌在内的所有细菌菌株均表现出更高的抗菌活性。环丙沙星和头孢他啶的最佳抗菌活性表现为与其他化合物相比具有更低的MIC和更低的MBC，或者表现为低MBC/MIC比值，这在临床实践中具有重要的临床优势。
