Derbyshire D R, Smith G, Achola K J
Br J Anaesth. 1987 Mar;59(3):300-4. doi: 10.1093/bja/59.3.300.
The catecholamine and cardiovascular responses to laryngoscopy and tracheal intubation have been studied in 30 patients undergoing elective gynaecological surgery, allocated randomly to one of three groups: group 1 received 4% lignocaine 160 mg using a Forrester Spray; group 2 received 4% lignocaine 160 mg by "Laryng-o-jet"; group 3 received an equal volume of saline administered by Forrester Spray. In all three groups, there were similar and statistically significant increases in mean arterial pressure and plasma adrenaline and noradrenaline concentrations 1 min after intubation, with diminution of these responses by 5 min after intubation. There were no differences between the three groups at any stage, which suggests that topical anaesthesia of the mucosa of the upper airway, as performed conventionally, is ineffective as a means of ameliorating the pressor and catecholamine responses to routine laryngoscopy and intubation.
对30例择期妇科手术患者进行了研究，观察儿茶酚胺及心血管系统对喉镜检查和气管插管的反应。这些患者被随机分为三组：第一组使用福雷斯特喷雾器接受4%利多卡因160毫克；第二组通过“喉喷注器”接受4%利多卡因160毫克；第三组使用福雷斯特喷雾器给予等量生理盐水。在所有三组中，插管后1分钟平均动脉压、血浆肾上腺素和去甲肾上腺素浓度均有相似且具有统计学意义的升高，插管后5分钟这些反应减弱。三组在任何阶段均无差异，这表明常规进行的上呼吸道黏膜表面麻醉作为减轻对常规喉镜检查和插管的升压及儿茶酚胺反应的一种方法是无效的。
