Matsunaga J, Bergman A, Bhatia N N
Br J Obstet Gynaecol. 1987 Feb;94(2):168-72. doi: 10.1111/j.1471-0528.1987.tb02345.x.
Fifty-one patients, 16 in the second trimester and 35 in the third, were treated by cryotherapy for genital condylomata acuminata; 19 of them had cervical cryotherapy in the second and third trimesters for cervical involvement. Cryosurgical treatment was performed on an out-patient basis, with no general anaesthesia or analgesia, and repeated every 2 weeks until resolution of the condylomata. Male partners were treated as necessary. Patients were followed every 2 weeks before and after delivery until 6 weeks postpartum. The newborn infants were examined for the presence of genital or laryngeal condylomata. Most women required two cryosurgical treatment sessions before complete resolution of condylomata; all resolved in pregnancy and no patient had residual disease at 6 weeks postpartum. There was no case of preterm premature rupture of membranes or premature delivery following cryotherapy, and no case of fetal injury. Labour and delivery were unaffected even by cervical cryotherapy.
51例尖锐湿疣患者接受了冷冻治疗，其中16例处于孕中期，35例处于孕晚期；其中19例在孕中期和孕晚期因宫颈受累接受了宫颈冷冻治疗。冷冻手术在门诊进行，无需全身麻醉或镇痛，每2周重复一次，直到疣体消退。必要时对男性伴侣进行治疗。患者在分娩前后每2周随访一次，直至产后6周。对新生儿进行检查，查看是否存在生殖器或喉部疣体。大多数女性在疣体完全消退前需要进行两次冷冻手术治疗；所有疣体在孕期均消退，且产后6周时无患者有残留病灶。冷冻治疗后未发生胎膜早破或早产病例，也无胎儿损伤病例。即使是宫颈冷冻治疗也未影响分娩过程。
