Department of General Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.
Department of Medical Imaging, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.
PeerJ. 2024 Jan 24;12:e16810. doi: 10.7717/peerj.16810. eCollection 2024.
This study aimed to examine the correlation between BRAF status and computed tomography (CT) imaging characteristics in papillary thyroid carcinoma (PTC) and determine if suspicious CT imaging features could predict BRAF status.
This retrospective study included patients with pathologically confirmed PTC at the Department of Thyroid Surgery of Zhongshan Hospital, Xiamen University, between July 2020 and June 2022. We compared the clinicopathologic factors and CT findings of nodules with and without the mutation, and the multiple logistical regression test was used to determine independent parameters of the BRAF mutation.
This study included 381 patients with PTC, among them, BRAF mutation was detected in 314 patients (82.4%). Multivariate logistic regression analysis showed that gender (OR = 0.542, 95% CI [0.296-0.993], = 0.047) and shape (OR = 0.510, 95% CI [0.275-0.944], = 0.032) were associated with BRAF mutation.
Compared to BRAF mutation-negative, BRAF-positive PTC lesions were more likely to be found in female patients and were characterized by irregular shape. However, the CT imaging finding is not enough to predict BRAF status, but an indication.
本研究旨在探讨甲状腺乳头状癌（PTC）中 BRAF 状态与计算机断层扫描（CT）成像特征的相关性，并确定可疑 CT 成像特征是否可预测 BRAF 状态。
本回顾性研究纳入了 2020 年 7 月至 2022 年 6 月在厦门大学附属中山医院甲状腺外科经病理证实为 PTC 的患者。我们比较了有突变和无突变结节的临床病理因素和 CT 发现，并使用多因素逻辑回归检验确定 BRAF 突变的独立参数。
本研究共纳入 381 例 PTC 患者，其中 314 例（82.4%）检测到 BRAF 突变。多因素逻辑回归分析显示，性别（OR=0.542，95%CI[0.296-0.993]， =0.047）和形状（OR=0.510，95%CI[0.275-0.944]， =0.032）与 BRAF 突变相关。
与 BRAF 突变阴性相比，BRAF 阳性 PTC 病变更可能发生在女性患者中，且形状不规则。然而，CT 成像发现不足以预测 BRAF 状态，仅为提示。
