Memi Tereza, Koletsos Nikolaos, Gerolymatou Nafsika, Karakosta Maria, Georgiadis Athanasios N, Drosos Alexandros A, Voulgari Paraskevi V
Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
Mediterr J Rheumatol. 2023 Sep 5;34(4):577-580. doi: 10.31138/mjr.050923.csa. eCollection 2023 Dec.
Polymyalgia Rheumatica (PMR) and Giant Cell Arteritis (GCA) are chronic inflammatory disorders that usually affect older people. Although the aetiology of these diseases remains unknown, genetic, environmental, and immune factors have been implicated. Specific cytokines such as the IL-6, IL-1β, IL-12, IL-17, and interferon -γ seem to play an essential role. The diagnosis of the disease is usually based on clinical manifestations and the use of histology or imaging, while disease monitoring is based on physical examination, laboratory, and imaging findings. However, there is the unmet need in identifying possible biomarkers that could help the diagnosis and the monitoring as well. The present study aims to investigate the epidemiological, clinical, and immunological characteristics of PMR and/or GCA patients in the region of northwest Greece and to evaluate the role of specific molecules associated with the pathogenesis of the diseases, giving evidence to possible future biomarkers.
风湿性多肌痛（PMR）和巨细胞动脉炎（GCA）是通常影响老年人的慢性炎症性疾病。尽管这些疾病的病因尚不清楚，但遗传、环境和免疫因素已被牵连其中。特定的细胞因子如白细胞介素-6、白细胞介素-1β、白细胞介素-12、白细胞介素-17和干扰素-γ似乎起着至关重要的作用。疾病的诊断通常基于临床表现以及组织学或影像学的应用，而疾病监测则基于体格检查、实验室检查和影像学检查结果。然而，在识别可能有助于诊断和监测的生物标志物方面仍存在未满足的需求。本研究旨在调查希腊西北部地区PMR和/或GCA患者的流行病学、临床和免疫学特征，并评估与疾病发病机制相关的特定分子的作用，为未来可能的生物标志物提供证据。
