Dadha Priyanka, Nimmagadda Sai, Venter Carina, Gupta Ruchi, Kumar Putcha Uday, Warren Christopher M
Center for Food Allergy & Asthma Research (CFAAR), Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
J Allergy Clin Immunol Glob. 2023 Dec 23;3(2):100204. doi: 10.1016/j.jacig.2023.100204. eCollection 2024 May.
Research on reported food-related triggers of atopic disease in South Asian adults is lacking despite the region's large population and the global significance of allergic diseases.
The study aimed to identify prevalent local food items and assess allergic sensitization rates to potential trigger foods for atopic diseases via skin prick and specific IgE testing.
The study began with a pilot survey of 100 subjects recruited from 4 hospitals in Hyderabad, India, focusing on foods perceived to relate to asthma, allergic rhinitis, atopic dermatitis, urticaria, and gastrointestinal allergic symptoms. A subsequent main study evaluated 2010 participants, 1754 of whom were diagnosed with an aforementioned atopic disease and who reported allergic symptoms related to any of 77 foods identified in the pilot study. Ultimately 1622 patients who consented to skin prick and specific IgE testing and who reported at least 1 food item triggering allergic diseases were included in the final analysis.
Among 1622 patients (average age, 42.6 ± 12.9 years; 55.5% male), asthma was the most commonly diagnosed atopic disease (26.4%), with itching and rash being frequently reported symptoms (22.7%). Notably, 94.9% of patients had total serum IgE > 144 kU/L. Chickpea, cabbage, eggplant, walnut, cumin, and betel leaf were the most commonly reported trigger foods.
In this sample of South Indian adults diagnosed with allergic disease, reported food triggers were most commonly local dietary staples, while reported reactions to priority allergens like peanut and sesame were conspicuously absent. Observed concordance between patient-reported food triggers and sensitization to reported food triggers was low, highlighting the need for improved clinical evaluation of suspected triggers.
尽管南亚地区人口众多且过敏性疾病具有全球意义，但针对南亚成年人中报告的与食物相关的特应性疾病触发因素的研究却很缺乏。
本研究旨在确定当地常见食物，并通过皮肤点刺试验和特异性IgE检测评估对特应性疾病潜在触发食物的过敏致敏率。
该研究首先对从印度海得拉巴的4家医院招募的100名受试者进行了试点调查，重点关注被认为与哮喘、过敏性鼻炎、特应性皮炎、荨麻疹和胃肠道过敏症状相关的食物。随后的主要研究评估了2010名参与者，其中1754人被诊断患有上述特应性疾病，且报告了与试点研究中确定的77种食物中的任何一种相关的过敏症状。最终，1622名同意进行皮肤点刺试验和特异性IgE检测且报告至少一种引发过敏性疾病的食物的患者被纳入最终分析。
在1622名患者中（平均年龄42.6±12.9岁；55.5%为男性），哮喘是最常见的特应性疾病（26.4%），瘙痒和皮疹是常见症状（22.7%）。值得注意的是，94.9%的患者血清总IgE>144 kU/L。鹰嘴豆、卷心菜、茄子、核桃、孜然和槟榔叶是最常报告的触发食物。
在这个被诊断患有过敏性疾病的南印度成年人样本中，报告的食物触发因素最常见的是当地的主食，而对花生和芝麻等主要过敏原的反应明显缺失。患者报告的食物触发因素与对报告的食物触发因素的致敏之间的一致性较低，这突出表明需要改进对疑似触发因素的临床评估。
