Agrawal Kaushal Kishor, Singh Neetu, Chand Pooran, Singh Saumyendra Vikram, Solanki Neeti, Garg Ravindra Kumar, Chaurasia Akhilanand
Department of Prosthodontics, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Centre for Advance Research, King George's Medical University, Lucknow, Uttar Pradesh, India.
J Taibah Univ Med Sci. 2023 Dec 27;19(2):313-320. doi: 10.1016/j.jtumed.2023.12.005. eCollection 2024 Apr.
Interleukin 1 (IL-1) and interleukin 6 (IL-6) gene polymorphisms have been suggested to be responsible for diminished bone mineral density (BMD) and high crestal bone loss (CBL) in some individuals. However, the effects of systemic BMD on variations in peri-implant CBL are unclear. Hence, this study was aimed at investigating the association of IL-1 and IL-6 gene polymorphisms with systemic BMD and CBL around dental implants.
A total of 190 participants undergoing dental implantation in the mandibular posterior region were selected according to predetermined selection criteria and divided into a normal BMD group (NBD, 93 participants, T-score ≥ -1) and low BMD group (LBD, including both osteoporosis and osteopenia, 97 participants, T-score < -1 standard deviation) according to the BMD of the right femoral neck, measured with dual-energy X-ray absorptiometry. Dental implants were placed through the standard surgical protocol, and CBL was calculated after 6 months with cone beam computed tomography scans before second-stage surgery. Genotyping was performed on all participants for IL-1A-889 A/G, IL-1B-511G/A, IL-1B+3954, and IL-6-572 C/G gene polymorphisms.
The demographic and clinical characteristics of the participants in both groups were compared with t-test and chi-square test (χ). The associations of NBD and LBD with the different genotypes and CBL was determined with odds ratios, and p < 0.05 was considered statistically significant. The frequency of IL-1B-511AA and IL-6-572 GG genotypes was significantly higher in LBD than in NBD (p < 0.05). In LBD, the IL-1B-511 AA (AA vs GA + GG; p ≤ 0.001) and IL-6-572 GG (GG vs CC + GC; p = 0.001) genotypes were significantly associated with higher peri-implant CBL.
Individuals with the IL-1B-511 AA or IL-6-572 GG genotype had elevated risk of osteoporosis/osteopenia and were more susceptible to CBL around dental implants.
白细胞介素1（IL-1）和白细胞介素6（IL-6）基因多态性被认为是导致某些个体骨密度（BMD）降低和牙槽嵴顶骨吸收（CBL）增加的原因。然而，全身骨密度对种植体周围CBL变化的影响尚不清楚。因此，本研究旨在探讨IL-1和IL-6基因多态性与种植体周围全身骨密度和CBL的关系。
根据预定的选择标准，选取190名下颌后牙区接受牙种植的参与者，根据双能X线吸收法测量的右股骨颈骨密度，将其分为正常骨密度组（NBD，93名参与者，T值≥ -1）和低骨密度组（LBD，包括骨质疏松症和骨质减少症，97名参与者，T值< -1标准差）。按照标准手术方案植入牙种植体，并在二期手术前6个月通过锥形束计算机断层扫描计算CBL。对所有参与者进行IL-1A -889 A/G、IL-1B -511G/A、IL-1B +3954和IL-6 -572 C/G基因多态性的基因分型。
两组参与者的人口统计学和临床特征采用t检验和卡方检验（χ）进行比较。用优势比确定NBD和LBD与不同基因型及CBL的关联，p < 0.05被认为具有统计学意义。LBD组中IL-1B -511AA和IL-6 -572 GG基因型的频率显著高于NBD组（p < 0.05）。在LBD组中，IL-1B -511 AA（AA与GA + GG相比；p≤0.001）和IL-6 -572 GG（GG与CC + GC相比；p = 0.001）基因型与种植体周围较高的CBL显著相关。
具有IL-1B -511 AA或IL-6 -572 GG基因型的个体患骨质疏松症/骨质减少症的风险升高，且更容易发生种植体周围CBL。
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