IL-1 和 TNFα 常见多态性与种植体周围疾病风险的关联：一项荟萃分析。
Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis.
机构信息
Department of Stomatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
PLoS One. 2021 Oct 5;16(10):e0258138. doi: 10.1371/journal.pone.0258138. eCollection 2021.
BACKGROUND
Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose.
METHODS
Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers.
RESULTS
Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17-2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19-2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15-2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72-10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35-2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05-2.95, p = 0.032) risk of IF/IL than non-carriers.
CONCLUSION
Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.
背景
促炎细胞因子白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNFα）在牙种植体骨整合过程中的宿主免疫反应和骨代谢中发挥重要作用。IL-1α、IL-1β 和 TNFα 的功能多态性是否与种植体周围疾病有关尚不清楚，我们为此进行了本次荟萃分析。
方法
在 2021 年 4 月 30 日之前，我们在多个文献数据库中搜索了与种植体周围疾病（包括种植体周围炎（PI）、边缘骨丧失（MBL）和种植体失败/丢失（IF/IL））相关的 IL-1α C-889T、IL-1β C+3954T 和 C-511T、TNFα G-308A 以及 IL-1α C-889T 和 IL-1β C+3954T 复合基因型的相关研究。我们在不同的遗传模型中计算了每个多态性与种植体周围疾病的比值比（OR）和相应的 95%置信区间（CI），并比较了携带者和非携带者的复合基因型。
结果
共纳入 27 项研究（1324 例种植体周围疾病患者和 1808 例健康种植体对照）。在所有遗传模型中，IL-1α C-889T 与种植体周围疾病均存在显著相关性。IL-1β C+3954T 等位基因（OR=1.66，95%CI 1.17-2.35，p=0.004）和显性模型（OR=1.74，95%CI 1.19-2.53，p=0.004）与种植体周围疾病风险相关，且在亚洲人、白种人、非吸烟者、IF/IL 和 PI 亚组中也存在相关性。与 CC+CT 基因型相比，IL-1β C-511T 的 TT 基因型增加了种植体周围疾病（OR=1.68，95%CI 1.15-2.43，p=0.007）和 MBL（OR=4.33，95%CI 1.72-10.9，p=0.002）的发病风险。我们未发现 TNFα G-308A 与种植体周围疾病之间存在显著相关性。与非携带者相比，IL-1α C-889T 和 IL-1β C+3954T 阳性复合基因型的携带者发生种植体周围疾病的风险增加了 1.95 倍（95%CI 1.35-2.80，p<0.001），IF/IL 的风险增加了 1.76 倍（95%CI 1.05-2.95，p=0.032）。
结论
IL-1α（C-889T）、IL-1β（C+3954T、C-511T）的功能多态性和 IL-1 的复合基因型可作为种植体周围疾病的预测标志物，而 TNFα G-308A 多态性与种植体周围疾病无关。
Zotero 插件