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根治性睾丸切除术后同侧阴囊复发性睾丸癌1例罕见病例

A Rare Case of Ipsilateral Scrotal Recurrence of Testicular Cancer After Radical Orchidectomy.

作者信息

Akpala Anna, Bhattacharyya Saloni, Damola Adebiyi, Viney Richard

机构信息

Urology, Queen Elizabeth Hospital Birmingham, Birmingham, GBR.

Urology, University of Birmingham, Birmingham, GBR.

出版信息

Cureus. 2023 Dec 28;15(12):e51219. doi: 10.7759/cureus.51219. eCollection 2023 Dec.

DOI:10.7759/cureus.51219
PMID:38283452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10821716/
Abstract

A lump in the testicle, painful or painless, could represent testicular cancer. Testicular cancer can be subdivided into germ-cell testicular cancer and sex cord-stromal tumors. A majority of testicular neoplasms are germ cell tumors (GCTs). GCTs are broadly divided into seminomatous and non-seminomatous germ cell tumors (NSGCTs) due to differences in natural history and treatment. Removal of the testis, also known as a radical orchidectomy, is often offered as part of the treatment for testicular cancer, which may be followed by additional medical treatment. It is not very common to have a recurrence of testicular cancer in the scrotum after a radical orchidectomy, and it is even rare to find this scrotal recurrence on the same side. An extensive literature review showed only one recorded case of scrotal recurrence of NSGCTs after orchidectomy but on the contralateral side. Here, we report the first case of scrotal recurrence of NSGCT after radical inguinal orchidectomy on the same side in a man who had orchidopexy in childhood. It is still unclear why testicular cancer could recur in the scrotum after a radical orchidectomy.

摘要

睾丸出现肿块,无论疼痛与否,都可能是睾丸癌。睾丸癌可细分为生殖细胞睾丸癌和性索间质肿瘤。大多数睾丸肿瘤是生殖细胞肿瘤(GCTs)。由于自然病史和治疗方法的差异,GCTs大致分为精原细胞瘤和非精原细胞生殖细胞肿瘤(NSGCTs)。切除睾丸,即根治性睾丸切除术,通常是睾丸癌治疗的一部分,术后可能还需要进一步的药物治疗。根治性睾丸切除术后,睾丸癌在阴囊复发的情况并不常见,在同侧发现阴囊复发的情况更为罕见。一项广泛的文献综述显示,仅记录到1例非精原细胞生殖细胞肿瘤(NSGCTs)睾丸切除术后阴囊复发的病例,但发生在对侧。在此,我们报告首例在儿童期接受过睾丸固定术的男性,行根治性腹股沟睾丸切除术后同侧阴囊出现NSGCTs复发的病例。目前仍不清楚为什么睾丸癌在根治性睾丸切除术后会在阴囊复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/10821716/e0438bcd44c4/cureus-0015-00000051219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/10821716/4600904951fa/cureus-0015-00000051219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/10821716/e0438bcd44c4/cureus-0015-00000051219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/10821716/4600904951fa/cureus-0015-00000051219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3003/10821716/e0438bcd44c4/cureus-0015-00000051219-i02.jpg

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Medicina (Kaunas). 2023 Apr 7;59(4):724. doi: 10.3390/medicina59040724.
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Testicular Cancer: Biology to Bedside.睾丸癌:从基础到临床。
Cancer Res. 2021 Nov 1;81(21):5369-5376. doi: 10.1158/0008-5472.CAN-21-1452. Epub 2021 Aug 11.
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Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer.根治性腹股沟睾丸切除术:睾丸癌初始治疗的金标准。
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Scrotal recurrence of germ cell tumour in a non-violated scrotum.非受侵犯阴囊内生殖细胞肿瘤的阴囊复发
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Eur J Cancer Care (Engl). 2009 May;18(3):322-4. doi: 10.1111/j.1365-2354.2008.01034.x. Epub 2009 Feb 24.
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Is scrotal violation per se a risk factor for local relapse and metastases in stage I nonseminomatous testicular cancer?对于I期非精原细胞瘤性睾丸癌,阴囊侵犯本身是否是局部复发和转移的危险因素?
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