Pasetes Lauren N, Goel Namni
Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.
J Sleep Res. 2024 Oct;33(5):e14149. doi: 10.1111/jsr.14149. Epub 2024 Jan 29.
For the first time, we determined whether actigraphic-assessed sleep measures show inter-individual differences and intra-individual stability during baseline (BL) and recovery (REC) phases surrounding repeated total sleep deprivation (TSD). We conducted a 5-day experiment at Months 2 and 4 in two separate studies (N = 11). During each experiment, sleep measures were collected via wrist actigraphy during two BL 8 h time-in-bed (TIB) nights (B1, B2) and during two REC 8-10 h TIB nights (R1, R2). Intraclass correlation coefficients (ICCs) assessed actigraphic measure long-term stability between 2 and 4 months for (1) the pre-experimental phase before BL; and (2) the BL (B1 + B2), REC (R1 + R2), and BL and REC average (BL + REC) phases; and short-term stability at Month 2 and at Month 4; and (3) between B1 versus B2 and R1 versus R2 in each 5-day experiment. Nearly all ICCs during the pre-experimental, BL, REC, and BL + REC phases were moderate to almost perfect (0.446-0.970) between Months 2 and 4. B1 versus B2 ICCs were more stable (0.440-0.899) than almost all R1 versus R2 ICCs (-0.696 to 0.588) at Month 2 and 4. Actigraphic sleep measures show phenotypic long-term stability during BL and REC surrounding repeated TSD between 2 and 4 months. Furthermore, within each 5-day experiment at Month 2 and 4, the two BL nights before TSD were more stable than the two REC nights following TSD, likely due to increased R1 homeostatic pressure. Given the consistency of actigraphic measures across the short-term and long-term, they can serve as biomarkers to predict physiological and neurobehavioral responses to sleep loss.
我们首次确定了在重复完全睡眠剥夺（TSD）前后的基线（BL）和恢复（REC）阶段，通过活动记录仪评估的睡眠指标是否存在个体间差异以及个体内稳定性。我们在第2个月和第4个月进行了两项独立研究（N = 11），为期5天的实验。在每个实验中，通过手腕活动记录仪在两个BL 8小时卧床（TIB）夜晚（B1、B2）以及两个REC 8 - 10小时TIB夜晚（R1、R2）收集睡眠指标。组内相关系数（ICC）评估了活动记录仪测量值在2至4个月期间的长期稳定性，针对（1）BL之前的实验前期阶段；（2）BL（B1 + B2）、REC（R1 + R2）以及BL和REC平均（BL + REC）阶段；以及在第2个月和第4个月的短期稳定性；（3）在每个5天实验中B1与B2之间以及R1与R2之间。在第2个月和第4个月期间，实验前期、BL、REC以及BL + REC阶段的几乎所有ICC均为中等至几乎完美（0.446 - 0.970）。在第2个月和第4个月，B1与B2的ICC比几乎所有R1与R2的ICC（-0.696至0.588）更稳定（0.440 - 0.899）。活动记录仪睡眠指标在2至4个月期间重复TSD前后的BL和REC阶段显示出表型长期稳定性。此外，在第2个月和第4个月的每个5天实验中，TSD前的两个BL夜晚比TSD后的两个REC夜晚更稳定，这可能是由于R1内稳态压力增加所致。鉴于活动记录仪测量值在短期和长期的一致性，它们可作为生物标志物来预测对睡眠剥夺的生理和神经行为反应。
