Key Laboratory for Food Microbial Technology of Zhejiang Province, College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, People's Republic of China.
Department of Food Science, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Compr Rev Food Sci Food Saf. 2024 Jan;23(1):e13292. doi: 10.1111/1541-4337.13292.
The human gastrointestinal (GI) tract microbiome secretes various metabolites that play pivotal roles in maintaining host physiological balance and influencing disease progression. Among these metabolites, bacteriocins-small, heat-stable peptides synthesized by ribosomes-are notably prevalent in the GI region. Their multifaceted benefits have garnered significant interest in the scientific community. This review comprehensively explores the methods for mining bacteriocins (traditional separation and purification, bioinformatics, and artificial intelligence), their effects on the stomach and intestines, and their complex bioactive mechanisms. These mechanisms include flora regulation, biological barrier restoration, and intervention in epithelial cell pathways. By detailing each well-documented bacteriocin, we reveal the diverse ways in which bacteriocins interact with the GI environment. Moreover, the future research direction is prospected. By further studying the function and interaction of intestinal bacteriocins, we can discover new pharmacological targets and develop drugs targeting intestinal bacteriocins to regulate and improve human health. It provides innovative ideas and infinite possibilities for further exploration, development, and utilization of bacteriocins. The inevitable fact is that the continuously exploration of bacteriocins is sure to bring the promising future for demic GI health understanding and interference strategy.
人类胃肠道（GI）微生物群分泌各种代谢物，这些代谢物在维持宿主生理平衡和影响疾病进展方面发挥着关键作用。在这些代谢物中，细菌素——核糖体合成的小而热稳定的肽——在 GI 区域特别普遍。它们多方面的益处引起了科学界的极大兴趣。
本综述全面探讨了细菌素的挖掘方法（传统的分离和纯化、生物信息学和人工智能）、它们对胃和肠道的影响以及它们复杂的生物活性机制。这些机制包括菌群调节、生物屏障修复和上皮细胞途径的干预。通过详细描述每个有充分文献记录的细菌素，我们揭示了细菌素与 GI 环境相互作用的多种方式。此外，还展望了未来的研究方向。通过进一步研究肠道细菌素的功能和相互作用，我们可以发现新的药理靶点，并开发针对肠道细菌素的药物来调节和改善人类健康。它为细菌素的进一步探索、开发和利用提供了创新的思路和无限的可能性。不可避免的事实是，对细菌素的不断探索必将为了解和干预 GI 健康带来充满希望的未来。
