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Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction.

作者信息

Washio Takuro, Hissen Sarah L, Takeda Ryosuke, Akins John D, Wakeham Denis J, Brazile Tiffany, Hearon Christopher M, MacNamara James P, Sarma Satyam, Levine Benjamin D, Fadel Paul J, Fu Qi

机构信息

Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, 7232 Greenville Ave., Ste. 435, Dallas, TX, 75231-8205, USA.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Clin Auton Res. 2024 Feb;34(1):223-226. doi: 10.1007/s10286-023-01013-0. Epub 2024 Jan 29.

DOI:10.1007/s10286-023-01013-0
PMID:38285071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11031183/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65ab/11031183/06e15419e84f/nihms-1985453-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65ab/11031183/06e15419e84f/nihms-1985453-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65ab/11031183/06e15419e84f/nihms-1985453-f0001.jpg

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Clin Auton Res. 2025 Feb 26. doi: 10.1007/s10286-025-01114-y.

本文引用的文献

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Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes.比较SGLT2抑制剂与氢氯噻嗪对2型糖尿病患者交感神经活动影响的随机试验
Kidney Int Rep. 2023 Sep 3;8(11):2254-2264. doi: 10.1016/j.ekir.2023.08.036. eCollection 2023 Nov.
2
Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure?在射血分数保留的心力衰竭中对血流动力学假说提出质疑:运动能力是否受肺毛细血管楔压升高的限制?
Circulation. 2023 Jan 31;147(5):378-387. doi: 10.1161/CIRCULATIONAHA.122.061828. Epub 2022 Dec 16.
3
Treatment of HFpEF beyond the SGLT2-Is: Does the Addition of GLP-1 RA Improve Cardiometabolic Risk and Outcomes in Diabetic Patients?
HFpEF 治疗:GLP-1RA 联合 SGLT2-I 是否可改善糖尿病患者的心血管代谢风险和结局?
Int J Mol Sci. 2022 Nov 23;23(23):14598. doi: 10.3390/ijms232314598.
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The Relationship Between the Blood-Brain-Barrier and the Central Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors.血脑屏障与胰高血糖素样肽-1受体激动剂和钠-葡萄糖协同转运蛋白2抑制剂的中枢效应之间的关系
Diabetes Metab Syndr Obes. 2022 Aug 22;15:2583-2597. doi: 10.2147/DMSO.S375559. eCollection 2022.
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2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2022年美国心脏协会/美国心脏病学会/美国心力衰竭学会心力衰竭管理指南:美国心脏病学会/美国心脏协会临床实践指南联合委员会报告
J Am Coll Cardiol. 2022 May 3;79(17):e263-e421. doi: 10.1016/j.jacc.2021.12.012. Epub 2022 Apr 1.
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GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition.GLP1R 通过颈动脉体抑制来减轻高血糖引起的交感神经反应。
Circ Res. 2022 Mar 4;130(5):694-707. doi: 10.1161/CIRCRESAHA.121.319874. Epub 2022 Feb 1.
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N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
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Diabetes Metab Syndr Obes. 2021 Jun 29;14:2955-2972. doi: 10.2147/DMSO.S312527. eCollection 2021.
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Neuroinflammation in heart failure: new insights for an old disease.心力衰竭中的神经炎症:旧病新见解。
J Physiol. 2020 Jan;598(1):33-59. doi: 10.1113/JP278864. Epub 2019 Dec 3.