Breasette M
Am J Med Technol. 1979 Jul;45(7):645-6.
The serodiagnosis of congenital syphilis is reviewed. Maternal history is the least reliable criterion for detecting congenital syphilis. A positive maternal history may or may not be valid; a negative maternal history does not rule out the possibility of congenital syphilis. Syphilis serology performed on the infant is a better criterion for detecting asymptomatic congenital syphilis or delayed onset. Serial VDRL titers on the infants are the best diagnostic tool presently available. A decreasing titer indicates the presence of maternally derived antibodies. The FTA-ABS (IgM) is still not sufficiently evaluated and standardized for routine clinical application.
本文综述了先天性梅毒的血清学诊断。母亲病史是检测先天性梅毒最不可靠的标准。母亲病史阳性可能有效也可能无效；母亲病史阴性不能排除先天性梅毒的可能性。对婴儿进行梅毒血清学检测是检测无症状先天性梅毒或迟发性先天性梅毒的更好标准。目前，婴儿连续的VDRL滴度是最佳诊断工具。滴度下降表明存在母体来源的抗体。FTA-ABS（IgM）在常规临床应用中仍未得到充分评估和标准化。
