Zou Minchao, Jiang Xinyu, Chen Haifeng, Yuan Fenghong
Department of Rheumatology and Immunology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Lupus. 2024 Mar;33(3):293-297. doi: 10.1177/09612033241230734. Epub 2024 Jan 29.
The aim is to investigate the clinical characteristics of systemic lupus erythematosus with intracranial hypertension.
The clinical characteristics of one case of systemic lupus erythematosus with chronic persistent intracranial hypertension were analyzed, and related literature was reviewed by searching Medline and Wanfang databases.
Intracranial hypertension in SLE patients may occur at the onset or during the course of the disease. Our patient was diagnosed with IH 3 years after the onset of SLE. Headache and papilledema were the most common symptoms of intracranial hypertension, followed by nausea or vomiting, vision changes, and cerebral palsy. Our patient had a headache and cranial hypertension that lasted for years, but no papilledema was found. Corticosteroid is currently the mainstay of the treatment of IIH in patients with SLE, and immunosuppressive agents, acetazolamide, intravenous mannitol and furosemide are also used. However, our patient did not respond to these treatments and presents the characteristics of chronic persistent intracranial hypertension.
Systemic lupus erythematosus with intracranial hypertension is a rare manifestation of SLE, which is not completely parallel to SLE activity. Headache and papilledema were the most common presenting symptoms. Different from previous reported cases, our patient had poor response to treatments, showing chronic and persistent characteristics.
探讨系统性红斑狼疮伴颅内高压的临床特征。
分析1例系统性红斑狼疮伴慢性持续性颅内高压患者的临床特征，并通过检索Medline和万方数据库复习相关文献。
系统性红斑狼疮患者颅内高压可能在疾病起病时或病程中出现。我们的患者在系统性红斑狼疮起病3年后被诊断为颅内高压。头痛和视乳头水肿是颅内高压最常见的症状，其次是恶心或呕吐、视力改变和脑瘫。我们的患者头痛和颅内高压持续数年，但未发现视乳头水肿。目前，糖皮质激素是系统性红斑狼疮患者治疗颅内高压的主要药物，也使用免疫抑制剂、乙酰唑胺、静脉注射甘露醇和呋塞米。然而，我们的患者对这些治疗无反应，并呈现慢性持续性颅内高压的特征。
系统性红斑狼疮伴颅内高压是系统性红斑狼疮的一种罕见表现，与系统性红斑狼疮活动并不完全平行。头痛和视乳头水肿是最常见的首发症状。与既往报道的病例不同，我们的患者对治疗反应不佳，表现为慢性和持续性特征。
