Xue Zheng, Wang Xuezhen, Liu Fei, Hu Shaoxian, Zhu Suiqiang, Zhang Suming, Bu Bitao
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):107-11. doi: 10.1007/s11596-009-0123-3. Epub 2009 Feb 18.
In order to better understand the clinical manifestation of systemic lupus erythematosus (SLE) with intracranial hypertension syndrome (IHS), we analyzed the clinical features and treatment of a typical SLE patient with IHS. SLE is one of the most unpredictable autoimmune diseases involving multiple organ systems that is defined clinically and associated with antibodies directed against cell nuclei. IHS is an uncommon manifestation of neuropsychiatric SLE (NPSLE) and is characterized by an elevated intracranial pressure, papilledema, and headache with occasional abducens nerve paresis, absence of a space-occupying lesion or ventricular enlargement, and normal cerebrospinal fluid chemical and hematological constituents. IHS has been reported in a few sporadic cases in patients with SLE worldwide, but rarely has been reported in China. In this study, a 34-year-old female SLE patient with IHS was reported and pertinent literature reviewed. The clinical presentation, image logical features, and investigatory findings were discussed.
为了更好地了解系统性红斑狼疮（SLE）合并颅内高压综合征（IHS）的临床表现，我们分析了1例典型的SLE合并IHS患者的临床特征及治疗情况。SLE是最难以预测的自身免疫性疾病之一，累及多个器官系统，临床诊断主要依据针对细胞核的抗体。IHS是神经精神性SLE（NPSLE）的一种罕见表现，其特征为颅内压升高、视乳头水肿、头痛，偶尔伴有展神经麻痹，无占位性病变或脑室扩大，脑脊液化学和血液成分正常。IHS在全球范围内的SLE患者中仅有少数散发病例报道，在中国则鲜有报道。本研究报告了1例34岁患有IHS的女性SLE患者，并对相关文献进行了回顾。对其临床表现、影像学特征及检查结果进行了讨论。
