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Kinetic simulation of anticancer drug effects on metabolic pathway fluxes: two case studies.

作者信息

Jackson R C

出版信息

Bull Math Biol. 1986;48(3-4):337-51. doi: 10.1007/BF02459686.

DOI:10.1007/BF02459686
PMID:3828562
Abstract
摘要

相似文献

1
Kinetic simulation of anticancer drug effects on metabolic pathway fluxes: two case studies.抗癌药物对代谢途径通量影响的动力学模拟:两个案例研究。
Bull Math Biol. 1986;48(3-4):337-51. doi: 10.1007/BF02459686.
2
Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate.接受N-(膦酰乙酰基)-L-天冬氨酸治疗患者组织中的天冬氨酸氨甲酰转移酶活性、药物浓度及嘧啶核苷酸
Biochem Pharmacol. 1982 Oct 15;31(20):3317-21. doi: 10.1016/0006-2952(82)90567-6.
3
The kinetic properties of switch antimetabolites.开关抗代谢物的动力学特性。
J Natl Cancer Inst. 1993 Apr 7;85(7):539-45. doi: 10.1093/jnci/85.7.539.
4
Therapy related disturbances in nucleotides in cancer cells.癌细胞中与治疗相关的核苷酸紊乱。
Adv Exp Med Biol. 1994;370:95-107. doi: 10.1007/978-1-4615-2584-4_24.
5
Clinical biochemical pharmacology of anticancer antimetabolites: introductory remarks.抗癌抗代谢物的临床生化药理学:引言
Bull Cancer. 1979;66(1):37-8.
6
Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells.N-(膦酰乙酰基)-L-天冬氨酸和吡唑呋林对完整细胞和通透细胞中嘧啶核糖核苷酸池和脱氧核糖核苷酸池的消耗动力学及其与核酸合成的关系。
Cancer Res. 1982 Nov;42(11):4525-31.
7
Salvage of circulating pyrimidine nucleosides in the rat.大鼠体内循环嘧啶核苷的挽救作用。
Cancer Res. 1981 Aug;41(8):3010-7.
8
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.嘌呤和嘧啶核苷酸代谢的抗代谢物在肿瘤细胞分化中的作用。
Biochem Pharmacol. 1999 Aug 15;58(4):539-55. doi: 10.1016/s0006-2952(99)00035-0.
9
[The biochemistry of the cancer cell. Purine and pyrimidine metabolism].[癌细胞的生物化学。嘌呤和嘧啶代谢]
Padiatr Padol. 1986;21(4):323-34.
10
Discovering switch pharmaceuticals from multistationary biochemical networks.从多稳态生化网络中发现开关药物。
J Natl Cancer Inst. 1993 Apr 7;85(7):518-9. doi: 10.1093/jnci/85.7.518.

引用本文的文献

1
SCoP: an interactive simulation control program for micro- and minicomputers.
Bull Math Biol. 1986;48(3-4):427-41. doi: 10.1007/BF02459691.

本文引用的文献

1
Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells.小鼠T淋巴瘤(S-49)细胞中的鸟嘌呤核苷酸耗竭与毒性
J Biol Chem. 1981 Aug 25;256(16):8713-7.
2
Kinetic simulation of anticancer drug interactions.抗癌药物相互作用的动力学模拟
Int J Biomed Comput. 1980 May;11(3):197-224. doi: 10.1016/0020-7101(80)90045-8.
3
Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: a network model for methotrexate action as a comprehensive example.
Pharmacol Ther. 1981;15(2):251-91. doi: 10.1016/0163-7258(81)90045-0.
4
A kinetic model of regulation of the deoxyribonucleoside triphosphate pool composition.脱氧核糖核苷三磷酸池组成调节的动力学模型。
Pharmacol Ther. 1984;24(2):279-301. doi: 10.1016/0163-7258(84)90038-x.
5
Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.分析甲氨蝶呤在体内肠道和艾氏腹水瘤中的膜转运及多聚谷氨酸化作用,作为药物敏感性和选择性的影响因素。
Cancer Res. 1983 Mar;43(3):1087-92.
6
Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.体内正常增殖和肿瘤性小鼠组织中氨甲蝶呤多聚谷氨酸酯的差异合成。
Cancer Res. 1981 Nov;41(11 Pt 1):4441-6.
7
Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis.抑制脱氧核糖核酸生物合成的药物相互作用的数学模拟
Mol Pharmacol. 1973 May;9(3):320-9.
8
Studies with a mathematical model of folate metabolism.关于叶酸代谢数学模型的研究。
Arch Biochem Biophys. 1973 Oct;158(2):827-41. doi: 10.1016/0003-9861(73)90579-1.
9
Mathematical simulation in chemotherapy.化疗中的数学模拟
Ann N Y Acad Sci. 1971 Nov 30;186:343-58. doi: 10.1111/j.1749-6632.1971.tb46989.x.
10
Enzyme kinetics and combination chemotherapy: an appraisal of current concepts.酶动力学与联合化疗:对当前概念的评估
Adv Enzyme Regul. 1975;13:77-96. doi: 10.1016/0065-2571(75)90009-6.