Jackson R C
Int J Biomed Comput. 1980 May;11(3):197-224. doi: 10.1016/0020-7101(80)90045-8.
A model is described that simulates the biochemical pathways of folate and nucleotide metabolism involved in DNA precursor biosynthesis. Examples are given of use of the model to study various aspects of the biochemical pharmacology of antitumour drugs. Modelling may be done in two ways: detailed simulation of all variables may be conducted for short time periods (less than 6 h of real time); alternatively, by assuming that concentrations of rapidly interconvertible metabolites remain close to steady-state proportions, time periods of several days may be modelled, facilitating simulation of cell growth in presence of drugs. Experiments designed to test predictions for these various types of study are described.
本文描述了一个模型，该模型模拟了参与DNA前体生物合成的叶酸和核苷酸代谢的生化途径。给出了使用该模型研究抗肿瘤药物生化药理学各个方面的示例。建模可以通过两种方式进行：可以在短时间内（小于6小时的实际时间）对所有变量进行详细模拟；或者，通过假设快速相互转化的代谢物浓度保持接近稳态比例，可以对几天的时间段进行建模，从而便于模拟药物存在下的细胞生长。描述了旨在检验这些不同类型研究预测结果的实验。
