Department of Cell Biology, Third Military Medical University, Chongqing, China.
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Nat Commun. 2024 Jan 29;15(1):864. doi: 10.1038/s41467-024-45144-y.
During myocardial infarction, microcirculation disturbance in the ischemic area can cause necrosis and formation of fibrotic tissue, potentially leading to malignant arrhythmia and myocardial remodeling. Here, we report a microchanneled hydrogel suture for two-way signal communication, pumping drugs on demand, and cardiac repair. After myocardial infarction, our hydrogel suture monitors abnormal electrocardiogram through the mobile device and triggers nitric oxide on demand via the hydrogel sutures' microchannels, thereby inhibiting inflammation, promoting microvascular remodeling, and improving the left ventricular ejection fraction in rats and minipigs by more than 60% and 50%, respectively. This work proposes a suture for bidirectional communication that acts as a cardio-patch to repair myocardial infarction, that remotely monitors the heart, and can deliver drugs on demand.
在心肌梗死中，缺血区域的微循环障碍可导致坏死和纤维组织形成，从而可能导致恶性心律失常和心肌重构。在这里，我们报告了一种用于双向信号通讯、按需泵送药物和心脏修复的微孔水凝胶缝线。心肌梗死后，我们的水凝胶缝线通过移动设备监测异常心电图，并通过水凝胶缝线的微通道按需触发一氧化氮，从而抑制炎症、促进微血管重构，使大鼠和小型猪的左心室射血分数分别提高了 60%和 50%以上。这项工作提出了一种作为心脏贴片修复心肌梗死的双向通讯缝线，它可以远程监测心脏并按需输送药物。
